fMRI studies of successful emotional memory encoding: A quantitative meta-analysis.
fMRI studies of successful emotional memory encoding: A quantitative meta-analysis.
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DOI：
10.1016/j.neuropsychologia.2010.07.030
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发表时间：
2010-10
期刊：
影响因子：
2.6
通讯作者：
LaBar KS
中科院分区：
文献类型：
--
作者：
Murty VP;Ritchey M;Adcock RA;LaBar KS
在过去的十年中，功能磁共振成像技术已经越来越多地用于询问成功的情绪记忆编码的神经相关性。这些研究通常旨在表征杏仁核和内侧颞叶（MTL）记忆系统的贡献，在动物中复制结果，或描绘特定行为现象的神经相关性。然而，将这些发现综合成系统神经科学的解释仍然很困难，即整个大脑的网络如何支持情绪对记忆编码的增强作用。为此，本研究采用了元分析的方法，使用激活可能性估计，以评估与成功的记忆编码的情感与中性信息的事件相关的功能磁共振成像激活的解剖特异性和可靠性。荟萃分析显示，一致的集群内的双侧杏仁核，海马前部，前部和后部海马旁回，腹侧视觉流，左侧前额叶皮层和右侧腹顶叶皮层。杏仁核和MTL的研究结果支持了动物文献中将这些区域与唤醒介导的记忆效应联系起来的大量发现。在皮质靶区（包括视觉、前额叶和顶叶皮质）的一致性研究结果强调了产生关于它们参与情绪记忆形成的假设的重要性。特别是，我们认为杏仁核与这些结构相互作用，以促进知觉处理，语义阐述和注意力的增强，这有助于随后的记忆情感材料。这些发现可能会激发未来对广泛神经系统的情绪调节以及这种调节对认知的影响的研究。
Over the past decade, fMRI techniques have been increasingly used to interrogate the neural correlates of successful emotional memory encoding. These investigations have typically aimed to either characterize the contributions of the amygdala and medial temporal lobe (MTL) memory system, replicating results in animals, or delineate the neural correlates of specific behavioral phenomena. It has remained difficult, however, to synthesize these findings into a systems neuroscience account of how networks across the whole brain support the enhancing effects of emotion on memory encoding. To this end, the present study employed a meta-analytic approach using activation likelihood estimates to assess the anatomical specificity and reliability of event-related fMRI activations related to successful memory encoding for emotional versus neutral information. The meta-analysis revealed consistent clusters within bilateral amygdala, anterior hippocampus, anterior and posterior parahippocampal gyrus, the ventral visual stream, left lateral prefrontal cortex and right ventral parietal cortex. The results within the amygdala and MTL support a wealth of findings from the animal literature linking these regions to arousal-mediated memory effects. The consistency of findings in cortical targets, including the visual, prefrontal, and parietal cortices, underscores the importance of generating hypotheses regarding their participation in emotional memory formation. In particular, we propose that the amygdala interacts with these structures to promote enhancements in perceptual processing, semantic elaboration, and attention, which serve to benefit subsequent memory for emotional material. These findings may motivate future research on emotional modulation of widespread neural systems and the implications of this modulation for cognition.
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影响因子：
2
作者：
Adolphs, R;Tranel, D;Denburg, N
通讯作者：
Denburg, N
DOI：
10.1073/pnas.93.15.8016
发表时间：
1996-07-23
影响因子：
11.1
作者：
Cahill, L;Haier, RJ;McGaugh, JL
通讯作者：
McGaugh, JL
DOI：
10.1073/pnas.162356599
发表时间：
2002-08-06
影响因子：
11.1
作者：
Canli, T;Desmond, JE;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
64.8
作者：
Anderson, AK;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
5.3
作者：
Bauer, Elizabeth P.;Paz, Rony;Pare, Denis
通讯作者：
Pare, Denis