Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).

Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).
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新小鼠T细胞生长因子的cDNA的克隆和表征(p40)。

DOI:
10.1084/jem.169.1.363
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发表时间:
1989-01-01
影响因子:
15.3
通讯作者:
SIMPSON, RJ
SIMPSON, RJ
中科院分区:
医学1区
文献类型:
--
作者:
VANSNICK, J;GOETHALS, A;RENAULD, JC;VANROOST, E;UYTTENHOVE, C;RUBIRA, MR;MORITZ, RL;SIMPSON, RJ

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最近,我们描述了一种具有T细胞生长因子活性的小鼠辅助T细胞衍生分子,该分子在功能和结构上不同于IL-2、IL-4和其他已知的生长因子。这个分子被命名为P40,被鉴定为一种糖蛋白,能够支持某些辅助性T细胞克隆的抗原非依赖性生长。在这里,我们报道了这种新的生长因子cDNA的克隆和表达。预测的成熟蛋白是一个阳离子的富含半胱氨酸的多肽,长度为14 kD,与先前测序的蛋白没有显著的同源性。
Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.
DOI: 10.1126/science.7302589
发表时间: 1981-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
SANGER, F
通讯作者: SANGER, F
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影响因子: 2.2
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发表时间: 1987-11-01
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影响因子: --
作者:
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通讯作者: Mosmann TR
DOI: 10.1073/pnas.85.18.6934
发表时间: 1988-09-01
影响因子: 11.1
作者:
UYTTENHOVE, C;SIMPSON, RJ;VANSNICK, J
通讯作者: VANSNICK, J
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发表时间: 1987-10-26
影响因子: 14.9
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