Stem cell review series: role of neurogenesis in age-related memory disorders.
Stem cell review series: role of neurogenesis in age-related memory disorders.
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DOI：
10.1111/j.1474-9726.2008.00369.x
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发表时间：
2008-08
期刊：
影响因子：
7.8
通讯作者：
Nora Abrous D
中科院分区：
文献类型：
--
作者：
Drapeau E;Nora Abrous D
神经可塑性的特点是树突的生长和分支，突触接触的重塑和神经发生，从而使大脑适应时间的变化。它在成年期得到维持，但在衰老过程中受到强烈抑制。在两个成人神经发生区，心室下区和齿状回，与年龄相关的神经发生下降尤为明显。这种与年龄相关的下降似乎主要归因于有限的增殖，与年龄相关的静止增加和/或细胞周期延长有关，并密切依赖于环境变化。事实上，当被适当的信号触发时，神经发生可以在衰老的大脑中重新激活，从而证实了与年龄相关的新神经元产生的减少不是一个不可逆转的细胞内在过程的观点。在衰老过程中，神经发生和与年龄相关的记忆缺陷（尤其是空间记忆）的共同进化支持了这样一种观点，即成人大脑中的新神经元参与记忆处理，而产生新神经元能力的下降导致了老年记忆缺陷的出现。此外，海马可塑性和功能的年龄相关变化受环境影响，可能有利于成功或病理性衰老。更好地了解调节神经发生的机制对于开发新的治疗工具来治疗或预防某些个体在衰老过程中可能出现的记忆障碍的发展是必要的。
Neuroplasticity is characterized by growth and branching of dendrites, remodeling of synaptic contacts, and neurogenesis, thus allowing the brain to adapt to changes over time. It is maintained in adulthood but strongly repressed during aging. An age-related decline in neurogenesis is particularly pronounced in the two adult neurogenic areas, the subventricular zone and the dentate gyrus. This age-related decline seems to be attributable mainly to limited proliferation, associated with an age-dependent increase in quiescence and/or a lengthening of the cell cycle, and is closely dependent on environmental changes. Indeed, when triggered by appropriate signals, neurogenesis can be reactivated in senescent brains, thus confirming the idea that the age-related decrease in new neuron production is not an irreversible, cell-intrinsic process. The coevolution of neurogenesis and age-related memory deficits – especially regarding spatial memory – during senescence supports the idea that new neurons in the adult brain participate in memory processing, and that a reduction in the ability to generate new neurons contributes to the appearance of memory deficits with advanced age. Furthermore, the age-related changes in hippocampal plasticity and function are under environmental influences that can favor successful or pathological aging. A better understanding of the mechanisms that regulate neurogenesis is necessary to develop new therapeutic tools to cure or prevent the development of memory disorders that may appear during the course of aging in some individuals.
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影响因子：
5.3
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
通讯作者：
Puche, Adam C.
DOI：
10.1016/0960-0760(90)90490-c
发表时间：
1990-11-20
影响因子：
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影响因子：
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作者：
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