Integrating DNA strand-displacement circuitry with DNA tile self-assembly.

Integrating DNA strand-displacement circuitry with DNA tile self-assembly.
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DOI:
10.1038/ncomms2965
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发表时间:
2013
影响因子:
16.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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DNA纳米技术已经成为一种可靠和可编程的方式,通过沃森-克里克碱基配对的特异性在纳米尺度上控制物质,允许具有纳米精度的复杂自组装结构和实现数字和模拟行为的复杂反应网络。在这里,我们展示了两个发展良好的框架,DNA瓦片自组装和DNA链位移电路,可以系统地集成,以提供可编程的自组装动力学控制。我们展示了由上游DNA催化剂网络激活的前体DNA双交叉瓦片触发和催化等温自组装超过10 μm长的DNA纳米管。集成更复杂的控制电路和瓦片系统可以实现动态分子结构的精确空间和时间组织。 DNA瓦片自组装和DNA链置换电路是DNA纳米技术中发展良好的框架。在这里,这两种方法相结合,给DNA纳米管自组装的可编程动力学控制。
DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing, allowing both complex self-assembled structures with nanometer precision and complex reaction networks implementing digital and analog behaviors. Here we show how two well-developed frameworks, DNA tile self-assembly and DNA strand-displacement circuits, can be systematically integrated to provide programmable kinetic control of self-assembly. We demonstrate the triggered and catalytic isothermal self-assembly of DNA nanotubes over 10 μm long from precursor DNA double-crossover tiles activated by an upstream DNA catalyst network. Integrating more sophisticated control circuits and tile systems could enable precise spatial and temporal organization of dynamic molecular structures. DNA tile self-assembly and DNA strand displacement circuits are well-developed frameworks in DNA nanotechnology. Here, the two approaches are combined to give programmable kinetic control of DNA nanotube self-assembly.
无酶DNA电路对多种检测方法的有理模块化适应。
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发表时间: 2011-09-01
影响因子: 14.9
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