Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms.
Iron-induced damage in cardiomyopathy: oxidative-dependent and independent mechanisms.
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DOI：
10.1155/2015/230182
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发表时间：
2015
影响因子：
--
通讯作者：
Cairo G
中科院分区：
文献类型：
--
作者：
Gammella E;Recalcati S;Rybinska I;Buratti P;Cairo G
含铁血黄素沉着患者心肌病的高发病率，特别是输注铁超载患者，强烈表明心脏中的铁积累在导致心力衰竭的过程中起着重要作用。在这种情况下，铁介导的有害活性氧的产生被认为是决定心肌细胞损伤的最重要的发病机制，是包括细胞凋亡、纤维化和最终心功能障碍的病理进展的起始事件。然而，最近的研究结果表明，涉及亚细胞细胞器和炎症介质的其他机制是该疾病发展的重要因素。此外，过量的铁可以放大其他药物或事件的心脏毒性作用。最后，心肌细胞内铁的亚细胞错误分布可能是导致心脏损伤的另一个途径。成像技术和螯合剂的最新进展分别显著改善了心脏铁过载的检测和治疗。然而，需要增加对铁过载心肌病致病机制的理解，为改进治疗策略的发展铺平道路。
The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure. In this context, iron-mediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damage, the initiating event of a pathologic progression involving apoptosis, fibrosis, and ultimately cardiac dysfunction. However, recent findings suggest that additional mechanisms involving subcellular organelles and inflammatory mediators are important factors in the development of this disease. Moreover, excess iron can amplify the cardiotoxic effect of other agents or events. Finally, subcellular misdistribution of iron within cardiomyocytes may represent an additional pathway leading to cardiac injury. Recent advances in imaging techniques and chelators development remarkably improved cardiac iron overload detection and treatment, respectively. However, increased understanding of the pathogenic mechanisms of iron overload cardiomyopathy is needed to pave the way for the development of improved therapeutic strategies.
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影响因子：
4.1
作者：
Devanur, Lakshmi D.;Evans, Robert W.;Hider, Robert C.
通讯作者：
Hider, Robert C.
影响因子：
4.1
作者：
CAIRO, G;RAPPOCCIOLO, E;SCHIAFFONATI, L
通讯作者：
SCHIAFFONATI, L
影响因子：
7.4
作者：
Coates TD
通讯作者：
Coates TD
DOI：
10.1056/nejmct1004810
发表时间：
2011-01-13
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brittenham GM
通讯作者：
Brittenham GM
影响因子：
39.3
作者：
Anderson, LJ;Holden, S;Pennell, DJ
通讯作者：
Pennell, DJ