Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease.
Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease.
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DOI：
10.1038/s41531-021-00254-y
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发表时间：
2021-12-08
期刊：
影响因子：
--
通讯作者：
Keshavarzian A
中科院分区：
文献类型：
--
作者：
Pal G;Ramirez V;Engen PA;Naqib A;Forsyth CB;Green SJ;Mahdavinia M;Batra PS;Tajudeen BA;Keshavarzian A
嗅觉功能障碍是帕金森病（PD）的运动前症状，在诊断前数年出现，并可能影响PD患者的生活质量。嗅球附近鼻腔深部微生物群的变化可能引发嗅球介导的神经炎症级联反应，最终导致PD患者的多巴胺丢失。为了确定与健康对照相比，PD的鼻腔深部微生物群是否发生了显著改变，我们使用16S rRNA基因扩增子测序对PD受试者的鼻腔深部微生物群进行了表征，并将其与配偶和非配偶健康对照进行了比较。还探讨了微生物分类群与PD症状严重程度之间的相关性。PD个体的嗅觉微生物群落与其配偶对照组比非家庭对照组更相似。在直接比较的PD和配偶的控制和PD和非配偶的控制，显着不同丰富的类群进行了鉴定，这包括增加相对丰度的推定机会致病菌种，如卡他莫拉菌。M.卡他症也与PD受试者中更严重的运动评分显著相关。这项概念验证研究提供的证据表明，在嗅球中检测到潜在的致病菌，并且PD微生物群群落的一部分变化可能是与PD生活相关的独特环境因素的结果。我们假设，改变的深鼻微生物群，其特征是一个假定的促炎微生物群落，可能会引发PD的神经炎症。
Olfactory dysfunction is a pre-motor symptom of Parkinson’s disease (PD) that appears years prior to diagnosis and can affect quality of life in PD. Changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade and eventual dopamine loss in PD. To determine if the deep nasal cavity microbiota of PD is significantly altered in comparison to healthy controls, we characterized the microbiota of the deep nasal cavity using 16S rRNA gene amplicon sequencing in PD subjects and compared it to that of spousal and non-spousal healthy controls. Correlations between microbial taxa and PD symptom severity were also explored. Olfactory microbial communities of PD individuals were more similar to those of their spousal controls than to non-household controls. In direct comparison of PD and spousal controls and of PD and non-spousal controls, significantly differently abundant taxa were identified, and this included increased relative abundance of putative opportunistic-pathobiont species such as Moraxella catarrhalis. M. catarrhalis was also significantly correlated with more severe motor scores in PD subjects. This proof-of-concept study provides evidence that potential pathobionts are detected in the olfactory bulb and that a subset of changes in the PD microbiota community could be a consequence of unique environmental factors associated with PD living. We hypothesize that an altered deep nasal microbiota, characterized by a putative pro-inflammatory microbial community, could trigger neuroinflammation in PD.
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DOI：
10.1002/mds.27105
发表时间：
2018-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Heintz-Buschart A;Pandey U;Wicke T;Sixel-Döring F;Janzen A;Sittig-Wiegand E;Trenkwalder C;Oertel WH;Mollenhauer B;Wilmes P
通讯作者：
Wilmes P
影响因子：
3.7
作者：
Chen W;Liu F;Ling Z;Tong X;Xiang C
通讯作者：
Xiang C
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
3.7
作者：
Hang, Jun;Zavaljevski, Nela;Keiser, Paul B.
通讯作者：
Keiser, Paul B.