High Serum Ferritin Levels Increase the Risk of Hyperuricemia: A Cross-Sectional and Longitudinal Study
High Serum Ferritin Levels Increase the Risk of Hyperuricemia: A Cross-Sectional and Longitudinal Study
复制标题
高血清铁蛋白水平会增加高尿酸血症的风险：一项横断面和纵向研究
DOI：
10.1159/000358337
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发表时间：
2014-03
影响因子：
3.9
通讯作者：
Li, Youming
中科院分区：
文献类型：
--
作者：
Zhang, Ya-nan;Xu, Chengfu;Xu, Lei;Yu, Chaohui;Miao, Min;Xie, Jianhong;Li, Youming
背景/目的：检查血清铁蛋白水平与高尿酸血症的横向和纵向关联。方法：对中国宁波镇海炼化公司的员工进行了横断面和前瞻性研究。在一项横断面研究中，分析了血清铁蛋白水平与高尿酸血症患病率之间的关联。每年对基线时没有高尿酸血症的受试者进行随访，以探讨血清铁蛋白水平与高尿酸血症发生率之间的前瞻性关联。结果：在基线入组的 10,074 名受试者中，1,731 名（17.18%）符合高尿酸血症的诊断标准。高尿酸血症受试者血清铁蛋白水平显着升高，且其水平与高尿酸血症患病率呈正相关。在总共 22,367 人年的随访中，502 名受试者出现高尿酸血症。在 1,000 人年的随访中，高尿酸血症的总体发生率为 22.4，范围从基线血清铁蛋白水平位于第一个五分位的受试者的 17.6 到第 2、3、4 和 5 个五分位的受试者的分别为 19.2、21.7、23.9 和 30.7（趋势 p < 0.001）。 Cox回归分析显示，血清铁蛋白水平与发生高尿酸血症的风险呈正相关。结论：我们的横断面和纵向结果表明，高血清铁蛋白水平会增加高尿酸血症的风险。
Background/Aims: To examine the cross-sectional and longitudinal associations of serum ferritin levels with hyperuricemia. Methods: A cross-sectional and subsequently prospective study was performed among the employees of Zhenhai Refining and Chemical Company, Ningbo, China. In a cross-sectional study, the association between serum ferritin levels and the prevalence of hyperuricemia was analyzed. Subjects who were free of hyperuricemia at baseline were followed up annually to explore the prospective association between serum ferritin levels and hyperuricemia incidence. Results: Of the 10,074 subjects enrolled at baseline, 1,731 (17.18%) fulfilled the diagnostic criteria of hyperuricemia. Subjects with hyperuricemia presented significantly higher serum ferritin levels, and the levels were positively correlated with the prevalence of hyperuricemia. During a total of 22,367 person-years of follow-up, 502 subjects developed hyperuricemia. The overall incidence of hyperuricemia for 1,000 person-years of follow-up was 22.4, ranging from 17.6 in subjects with baseline serum ferritin levels in the first quintile to 19.2, 21.7, 23.9, and 30.7 in subjects in quintiles 2, 3, 4, and 5, respectively (p for trend < 0.001). Cox regression analyses showed that serum ferritin levels were positively associated with the risk of incident hyperuricemia. Conclusions: Our cross-sectional and longitudinal results indicate that high serum ferritin levels increase the risk of hyperuricemia.
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影响因子：
3.7
作者：
Jung CH;Lee MJ;Hwang JY;Jang JE;Leem J;Park JY;Lee J;Kim HK;Lee WJ
通讯作者：
Lee WJ
DOI：
10.3122/jabfm.2011.04.110015
发表时间：
2011-07
期刊：
The Journal of the American Board of Family Medicine
影响因子：
--
作者：
A. Mainous;Michele E. Knoll;C. J. Everett;Eric M. Matheson;M. Hulihan;Althea M. Grant
通讯作者：
A. Mainous;Michele E. Knoll;C. J. Everett;Eric M. Matheson;M. Hulihan;Althea M. Grant
影响因子：
16.2
作者：
Park SK;Ryoo JH;Kim MG;Shin JY
通讯作者：
Shin JY
影响因子：
3.2
作者：
Muscelli, E;Natali, A;Ferrannini, E
通讯作者：
Ferrannini, E
影响因子：
25.7
作者：
Li, Youming;Xu, Chengfu;Miao, Min
通讯作者：
Miao, Min