Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study.
Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study.
复制标题
DOI：
10.2337/dc12-0543
复制
发表时间：
2012-12
期刊：
影响因子：
16.2
通讯作者：
Shin JY
中科院分区：
文献类型：
--
作者：
Park SK;Ryoo JH;Kim MG;Shin JY
已知血清铁蛋白升高与代谢综合征(METS)的流行有关。然而，还没有研究证实血清铁蛋白水平是否确实与甲胎蛋白综合征的未来发展有关。因此，我们开展了一项前瞻性研究，以评估基线血清铁蛋白水平对蛋氨酸代谢综合征发生的纵向影响。一组18022名健康的韩国男性没有服用METS，他们在2005年参加了一项健康体检计划，跟踪调查一直持续到2010年。METS是根据国际糖尿病联合会流行病学和预防工作组的联合中期声明定义的。采用COX比例风险模型。在45,919.3人年的跟踪调查中，2006至2010年间发生了2,127起大都会传染病病例。在调整多个协变量后，比较血清铁蛋白水平的第二个五分位数和第五个五分位数与第一个五分位数的危险比(95%CI)分别为1.19(0.98-1.45)、1.17(0.96-1.43)、1.36(1.12-1.65)和1.66(1.38-2.01)(趋势分析和t；0.001)。这些关联在临床相关的亚组分析中是明显的。在5年的随访期内，血清铁蛋白水平升高与甲胎蛋白综合征的未来发展独立相关。
Elevated serum ferritin has been known to be associated with the prevalence of metabolic syndrome (MetS). However, there was no research to examine whether serum ferritin levels have been actually associated with the prospective development of MetS. Accordingly, we carried out a prospective study to evaluate the longitudinal effects of baseline serum ferritin levels on the development of MetS. A MetS-free cohort of 18,022 healthy Korean men, who had participated in a medical health checkup program in 2005, was followed until 2010. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Cox proportional hazards models were performed. During 45,919.3 person-years of follow-up, 2,127 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% CI) for incident MetS comparing the second quintile to the fifth quintile of serum ferritin levels versus the first quintile were 1.19 (0.98–1.45), 1.17 (0.96–1.43), 1.36 (1.12–1.65), and 1.66 (1.38–2.01), respectively (P for trend <0.001). These associations were apparent in the clinically relevant subgroup analyses. Elevated serum ferritin levels were independently associated with future development of MetS during the 5-year follow-up period.
登录
查看更多内容
影响因子：
5.3
作者：
Halle, M;Konig, D;Baumstark, MW
通讯作者：
Baumstark, MW
影响因子：
7.7
作者：
Ford, ES;Mokdad, AH;Brown, DW
通讯作者：
Brown, DW
影响因子：
5.8
作者：
Sun, Liang;Franco, Oscar H.;Lin, Xu
通讯作者：
Lin, Xu
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
16.2
作者：
Jehn, M;Clark, JM;Guallar, E
通讯作者：
Guallar, E