Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
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DOI：
10.1371/journal.pone.0075250
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee WJ
中科院分区：
文献类型：
--
作者：
Jung CH;Lee MJ;Hwang JY;Jang JE;Leem J;Park JY;Lee J;Kim HK;Lee WJ
铁蛋白浓度升高与2型糖尿病的病因有关。越来越多的证据（主要来自对西方人群进行的研究）表明，铁蛋白浓度升高与2型糖尿病发病率之间存在密切联系。然而，在亚洲人群中，缺乏调查血清铁蛋白水平升高与2型糖尿病之间关系的纵向研究。在本研究中，我们旨在确定韩国健康男性血清铁蛋白水平升高是否与2型糖尿病的发生有关。这项为期4年的纵向观察研究是在韩国首尔牙山医疗中心进行的。研究人群包括2,029名无2型糖尿病的男性，他们在2007年（基线）和2011年（随访）接受了常规健康检查。采用化学发光双点夹心免疫分析法测定血清铁蛋白基线浓度。在多重调整模型中，即使在调整了胰岛素抵抗的稳态模型评估等混杂变量后，高铁蛋白四分位数组发生2型糖尿病的相对危险度（RR）也显著高于低铁蛋白四分位数组（RR = 2.17, 95%置信区间1.27-3.72，P为趋势值= 0.013）。这些结果表明，在亚洲人群中，血清铁蛋白基线水平升高与2型糖尿病的发生有关。
Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men. This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27–3.72, P for trend = 0.013). These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.
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影响因子：
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