Exercise effect on canine and miniswine cardiac catecholamines and enkephalins.
Exercise effect on canine and miniswine cardiac catecholamines and enkephalins.
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运动对犬和小型猪心脏儿茶酚胺和脑啡肽的影响。
DOI：
10.1097/00005768-199710000-00010
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发表时间：
1997
影响因子：
4.1
通讯作者：
Gwirtz,PA
中科院分区：
文献类型：
--
作者：
Barron,BA;Laughlin,MH;Gwirtz,PA
慢性运动改变心脏功能和对自主控制的反应性。儿茶酚胺和脑啡肽是参与自主调节和信号传导的神经内分泌递质。我们假设运动训练引起的交感神经刺激的间歇性增加会降低心脏的儿茶酚胺和脑啡肽含量。狗和小型猪进行运动训练，心脏提取的儿茶酚胺和脑啡肽的测量。在犬心脏中，心房的儿茶酚胺含量大于心室的含量，这与心房的神经元密度较大是一致的。相比之下，猪肾上腺素含量均匀分布在心脏切片上，右侧的去甲肾上腺素含量高于左侧。小型猪和犬心肌中儿茶酚胺含量在运动训练后的变化不同。犬心脏去甲肾上腺素含量降低，猪心脏去甲肾上腺素含量升高。这表明小型猪与犬的心脏肾上腺素能控制存在差异。甲硫氨酸脑啡肽（met-enk）在犬心脏中的分布是均匀的，不像小型猪，心房比心室含有更多。前脑啡肽加工产生四个甲硫氨酸-脑啡肽序列和一个甲硫氨酸-脑啡肽-精氨酸-苯丙氨酸;尽管如此，这两个物种的脑室含有更多的甲硫氨酸-脑啡肽-精氨酸-苯丙氨酸比甲硫氨酸-脑啡肽的免疫反应性。因此，脑啡肽原在心脏组织中的加工是不完全的。狗的运动训练导致心脏met-enk减少，左心房met-enk-arg-phe减少，心室met-enk-arg-phe增加。猪心脑啡肽浓度没有变化的训练。脑啡肽的变化可以通过脑啡肽原加工和/或释放的变化来解释。Met-enk-arg-phe特别擅长调节犬心脏的迷走神经刺激。运动训练后观察到的组织含量的变化可能是运动引起的心脏自主神经张力变化的结果。这些数据表明，植物神经调节的物种依赖性变化。
Chronic exercise changes cardiac function and responsiveness to autonomic control. Catecholamines and enkephalins are neuroendocrine transmitters involved in autonomic regulation and signaling. We hypothesized that intermittent increased sympathetic stimulation caused by exercise training would decrease cardiac catecholamine and enkephalin content. Dogs and miniswine were exercise trained and hearts extracted for catecholamine and enkephalin measurements. Atrial catecholamine content is greater than ventricular content in dog heart which is in keeping with the greater atrial neuronal density. In contrast, porcine epinephrine content was evenly distributed across heart sections and norepinephrine content was greater on the right side than the left. Changes in miniswine and dog heart catecholamine content after exercise training were different. Canine cardiac norepinephrine content decreased and porcine norepinephrine content increased. This indicates a difference in cardiac adrenergic control in miniswine versus canines. Methionine-enkephalin (met-enk) distribution across canine heart is uniform, unlike the miniswine, where the atria contain more than the ventricles. Proenkephalin processing produces four met-enk sequences and one met-enk-arg-phe; despite this, ventricles of both species contain more met-enk-arg-phe immunoreactivity than met-enk. Therefore, proenkephalin processing is incomplete in heart tissue. Exercise training in the dog resulted in decreased cardiac met-enk, decreased left atrial met-enk-arg-phe, and increased ventricular met-enk-arg-phe. Porcine cardiac enkephalin concentration was unchanged by training. The changes in the enkephalins may be explained by changes in proenkephalin processing and/or release. Met-enk-arg-phe is particularly good at modulating vagal stimulation of the canine heart. The changes in tissue content seen after exercise training may be a result of the exercise-induced change in autonomic tone to the heart. These data suggest species dependent changes in autonomic regulation.
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DOI：
--
发表时间：
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期刊：
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