Chronotype and social jetlag influence human circadian clock gene expression.
Chronotype and social jetlag influence human circadian clock gene expression.
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DOI：
10.1038/s41598-018-28616-2
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发表时间：
2018-07-05
影响因子：
4.6
通讯作者：
Shibata S
中科院分区：
文献类型：
--
作者：
Takahashi M;Tahara Y;Tsubosaka M;Fukazawa M;Ozaki M;Iwakami T;Nakaoka T;Shibata S
我们研究了生物钟类型或社会时差与生物钟基因表达之间的关系。24名年轻男性[时间类型：早晨型，n = 8;中间型，n = 8，晚上型，n = 8]，年龄27 ± 2岁（平均值± SE），以随机顺序完成两项试验：（1）周五试验和（2）周一试验。在这两项试验中，收集毛囊细胞以评估24小时内每隔4小时的时钟基因表达。在晨起组中，NR 1D 1、NR 1D 2和PER 3的表达受时间的主效应影响显著（P < 0.001），而在晚上组中则无此效应。NR 1D 1（r = 0.434，P = 0.034）、NR 1D 2（r = 0.481，P = 0.017）和PER 3（r = 0.457，P = 0.025）表达高峰时间的变化与社交时差（SJL）时间呈正相关。我们的研究结果表明，在晨兴组中，工作日和假期后第二天之间的时钟基因表达模式没有变化，并且SJL时间影响时钟基因表达的高峰时间，将其从工作日的早期移动到假期后的晚期。
We examined the relationships between chronotype or social jetlag and clock gene expression. Twenty-four young men [Chronotype: morningness, n = 8; intermediate, n = 8, eveningness, n = 8], aged 27 ± 2 years old (mean ± SE), completed two trials in a randomized order: (1) a Friday trial and (2) a Monday trial. In both trials, hair follicle cells were collected to evaluate the expression of clock genes over a 24-hour period at 4-hour intervals. There was a significant main effect of time on the expression of NR1D1, NR1D2, and PER3 (P < 0.001) in the morningness group, but not in the eveningness group. Changes in the peak time of expression of NR1D1 (r = 0.434, P = 0.034), NR1D2 (r = 0.481, P = 0.017), and PER3 (r = 0.457, P = 0.025) from the Friday to Monday trials were positively correlated with social jetlag (SJL) time. Our findings indicate that there was no change in the patterns of clock gene expression between workdays and the day after the holiday in the morningness group, and that SJL time influences the peak time of clock gene expression, moving it from the early to late workday, after a holiday.
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DOI：
10.1017/s0007114516002117
发表时间：
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期刊：
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DOI：
10.1126/science.1195027
发表时间：
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期刊：
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