Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex.
Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex.
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DOI：
10.1016/j.biopsych.2010.06.018
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发表时间：
2010-10-01
影响因子：
10.6
通讯作者：
Hong, L. Elliot
中科院分区：
文献类型：
--
作者：
Zhang, Xiaochu;Stein, Elliot A.;Hong, L. Elliot
关键词：
尽管精神分裂症患者吸烟的风险很高，但这种共病关联的神经生物学基础尚不清楚。精神分裂症和吸烟人群的白质异常已被独立描述。我们试图确定吸烟和精神分裂症是否与类似的白质异常相关，这些异常可能是精神分裂症吸烟高风险的生物标志物。研究人员测量了 46 名精神分裂症患者（32 名吸烟者和 14 名非吸烟者）和 69 名年龄匹配的健康对照者（48 名吸烟者和 21 名非吸烟者）的全脑白质完整性（分数各向异性 [FA]）。精神分裂症和吸烟状态与左前丘脑辐射/内囊前肢的 FA 减少独立且相加相关，而精神分裂症的双侧钩束/额枕下束和吸烟状态的左前额叶区分别发现 FA 显着减少。白质受损的常见和独特模式与精神分裂症和吸烟有关。特别是，丘脑前辐射/内囊前肢中附加白质异常的解剖学一致性表明，额叶皮层和纹状体/丘脑之间的这种异常纤维连接可能是精神分裂症患者共病吸烟增加的生物标志物。
Although schizophrenia patients are at high risk for tobacco use, the neurobiological basis of this comorbid association is not clear. White matter abnormalities have been described independently in schizophrenia and smoking cohorts. We sought to determine whether smoking and schizophrenia are associated with similar white matter abnormalities that could be biomarkers for the high risk of smoking in schizophrenia. Whole brain white matter integrity (fractional anisotropy [FA]) was measured in 46 schizophrenia patients (32 smokers and 14 nonsmokers) and 69 healthy age matched controls (48 smokers and 21 nonsmokers). Schizophrenia and smoking status were independently and additively associated with reduced FA in left anterior thalamic radiation/anterior limb of the internal capsule, while significant FA decreases were identified in the bilateral uncinate fasciculus/inferior fronto-occipital fasciculus in schizophrenia and the left prefrontal area in smoking status separately. Common and distinct patterns of impaired white matter are associated with schizophrenia and smoking. Particularly, the anatomical congruence of an additive white matter abnormality in the anterior thalamic radiation/anterior limb of the internal capsule suggests that this abnormal fiber connectivity between frontal cortex and striatum/thalamus may be a biomarker for the increased comorbid smoking in schizophrenia patients.
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影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
8.3
作者：
Fukuda, H;Kitani, M
通讯作者：
Kitani, M
影响因子：
10.6
作者：
Jacobsen, LK;Krystal, JH;Pugh, KR
通讯作者：
Pugh, KR
影响因子：
5.8
作者：
Rollema, Hans;Hajos, Mihaly;Williams, Kathryn E.
通讯作者：
Williams, Kathryn E.
影响因子：
5.4
作者：
Sussmann, Jessika E.;Lymer, G. Katherine S.;McIntosh, Andrew M.
通讯作者：
McIntosh, Andrew M.