Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes.
Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes.
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DOI：
10.1371/journal.pntd.0006197
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发表时间：
2018-01
影响因子：
3.8
通讯作者：
Hamano S
中科院分区：
文献类型：
--
作者：
Moriyasu T;Nakamura R;Deloer S;Senba M;Kubo M;Inoue M;Culleton R;Hamano S
疟疾和血吸虫病是热带地区造成发病和死亡的主要寄生虫病。流行病学调查显示，撒哈拉以南非洲儿童的合并感染率高达30%。为了研究这两种寄生虫共感染对疾病流行病学和病理学的影响，我们在小鼠中使用约氏疟原虫和曼氏血吸虫进行了共感染研究。疟原虫子孢子接种后在小鼠肝脏中的生长被显著抑制。因此，当接种少量子孢子时，继续发展为血液期疟疾的小鼠的百分比大幅降低。此外，配子体的感染性大大降低，在小鼠与S。曼氏感染。这些结果对了解疟原虫和血吸虫物种之间的相互作用具有深远的意义，并对疟疾流行地区的疟疾控制具有影响。疟疾和血吸虫病是寄生虫感染性疾病，在热带地区造成严重的发病率和死亡率。慢性血吸虫病会导致儿童营养不良和智力发育受损，而疟疾会导致致命的急性感染。由于这两种寄生虫的共感染在热带地区很常见，因此已经进行了许多流行病学和动物模型共感染的研究，以揭示它们之间的相互作用。以往关于疟原虫和血吸虫寄生虫之间相互作用的动物研究集中在疟疾感染的血液阶段病理学上，并且一致表明寄生虫血症可以在蠕虫存在下增强。相反，我们专注于血吸虫和疟原虫混合感染小鼠肝脏的免疫病理学。我们证明了S.曼氏感染抑制了疟原虫寄生虫在肝脏中的生长，导致在接种少量子孢子后继续发展为血液期疟疾的小鼠的百分比大大降低。我们还证明，配子体的感染性大大降低，在小鼠与S。曼氏感染。我们的结果表明S.曼氏感染可以减少疟疾从蚊子到老鼠以及从老鼠到蚊子的传播。
Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics. Epidemiological surveys have revealed coinfection rates of up to 30% among children in Sub-Saharan Africa. To investigate the impact of coinfection of these two parasites on disease epidemiology and pathology, we carried out coinfection studies using Plasmodium yoelii and Schistosoma mansoni in mice. Malaria parasite growth in the liver following sporozoite inoculation is significantly inhibited in mice infected with S. mansoni, so that when low numbers of sporozoites are inoculated, there is a large reduction in the percentage of mice that go on to develop blood stage malaria. Furthermore, gametocyte infectivity is much reduced in mice with S. mansoni infections. These results have profound implications for understanding the interactions between Plasmodium and Schistosoma species, and have implications for the control of malaria in schistosome endemic areas. Malaria and schistosomiasis are parasitic infectious diseases that cause severe morbidity and mortality in the tropics. Chronic schistosomiasis causes malnutrition and impaired intellectual development to children while malaria can cause fatal acute infections. Since coinfection of these two parasites is common in the tropics, many studies of both epidemiology and coinfection in animal models have been performed in order to reveal interactions between them. Previous animal studies on the interactions between Plasmodium and Schistosoma parasites have focused on the blood stage pathology of the malaria infection, and have consistently shown that parasitaemia can be enhanced in the presence of the helminth. In contrast, we focused on liver immunopathology in mice during coinfection between with Schistosoma and Plasmodium. We show that S. mansoni infection inhibits Plasmodium parasite growth in the liver resulting in a large reduction in the percentage of mice that go on to develop blood stage malaria following inoculation of low numbers of sporozoites. We also demonstrate that gametocyte infectivity is much reduced in mice with S. mansoni infections. Our results imply that S. mansoni infection can reduce malaria transmission both from mosquitoes to mice, and from mice to mosquitoes.
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影响因子：
9.6
作者：
Druilhe, P;Tall, A;Sokhna, C
通讯作者：
Sokhna, C
DOI：
10.4269/ajtmh.2005.73.1124
发表时间：
2005-12-01
影响因子：
3.3
作者：
Lyke, KE;Dicko, A;Doumbo, OK
通讯作者：
Doumbo, OK
影响因子：
30.3
作者：
Butler NS;Schmidt NW;Vaughan AM;Aly AS;Kappe SH;Harty JT
通讯作者：
Harty JT
影响因子：
5.2
作者：
Gomes PS;Bhardwaj J;Rivera-Correa J;Freire-De-Lima CG;Morrot A
通讯作者：
Morrot A
DOI：
10.4269/ajtmh.2005.72.702
发表时间：
2005-06-01
影响因子：
3.3
作者：
Briand, V;Watier, L;Cot, M
通讯作者：
Cot, M