Resistance to forgetting associated with hippocampus-mediated reactivation during new learning.
Resistance to forgetting associated with hippocampus-mediated reactivation during new learning.
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DOI：
10.1038/nn.2498
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发表时间：
2010-04
影响因子：
25
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
Kuhl, Brice A.;Shah, Arpeet T.;DuBrow, Sarah;Wagner, Anthony D.
我们忘记过去经历的一个主要原因是我们在此期间获得了新的记忆。虽然海马体被认为在获取和保留过去的记忆方面起着主要作用，但几乎没有证据表明新学习过程中的神经操作与对早期事件的遗忘（或记忆）有关。在这里，我们提出了新的证据，在编码新的记忆，在人类海马体的反应是预测的记忆保留以前经历过的，重叠的事件。这种大脑-行为关系在对个体事件的神经反应和个体差异中很明显。我们举例说明，海马体通过在新记忆形成时重新激活旧记忆来实现这一功能，在这种情况下，重新激活代表与旧记忆相关的金钱奖励的神经反应。这些数据揭示了一种基本的机制，海马体通过这种机制在获得新记忆时调节对旧记忆的遗忘。
A primary reason we forget past experiences is because we acquire new memories in the interim. While the hippocampus is thought to play a primary role in acquiring and retaining memories for the past, there is little evidence linking neural operations during new learning to the forgetting (or remembering) of earlier events. Here we present novel evidence that, during the encoding of new memories, responses within the human hippocampus are predictive of the retention of memories for previously experienced, overlapping events. This brain-behavior relationship is evident in neural responses to individual events and in differences across individuals. We illustrate that the hippocampus accomplishes this function by reactivating older memories as new memories are formed—in this case, reactivating neural responses that represent monetary rewards associated with older memories. These data reveal a fundamental mechanism through which the hippocampus tempers the forgetting of older memories as newer memories are acquired.
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