Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousal.
Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousal.
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DOI：
10.1162/jocn.2010.21527
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发表时间：
2011-05
影响因子：
3.2
通讯作者：
Barrett LF
中科院分区：
文献类型：
--
作者：
Moriguchi Y;Negreira A;Weierich M;Dautoff R;Dickerson BC;Wright CI;Barrett LF
新出现的证据表明，刺激的新颖性是有效的，并且可靠地参与杏仁核和大脑中情感工作区的其他部分。使用功能磁共振成像，我们检查了新奇刺激是否在整个生命周期中仍然有效，因此，新奇处理-一种潜在的生存相关功能-是否随着年龄的增长而保留。19名年轻和22名年长的健康成人在观察新的和熟悉的情感图片时进行扫描，同时估计自己主观体验的唤起水平。我们研究了杏仁核中BOLD反应的激活幅度、血流动力学时间过程和功能连通性的年龄相关差异。尽管杏仁核对新奇事物的峰值反应没有年龄相关的差异，但老年人在对新奇刺激的反应中表现出更窄、更尖锐（即“更尖峰”）的血流动力学时间过程，并且左杏仁核与包括眶额区在内的情感区域之间的连通性下降。这些发现对于理解与年龄相关的记忆差异和影响调节具有相关性。
Emerging evidence indicates that stimulus novelty is affectively potent and reliably engages the amygdala and other portions of the affective workspace in the brain. Using fMRI, we examined whether novel stimuli remain affectively salient across the lifespan, and therefore, whether novelty processing—a potentially survival-relevant function—is preserved with aging. Nineteen young and 22 older healthy adults were scanned during observing novel and familiar affective pictures while estimating their own subjectively experienced aroused levels. We investigated age-related difference of magnitude of activation, hemodynamic time course, and functional connectivity of BOLD responses in the amygdala. Although there were no age-related differences in the peak response of the amygdala to novelty, older individuals showed a narrower, sharper (i.e., “peakier”) hemodynamic time course in response to novel stimuli, as well as decreased connectivity between the left amygdala and the affective areas including orbito-frontal regions. These findings have relevance for understanding age-related differences in memory and affect regulation.
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影响因子：
16.2
作者：
Breiter, HC;Etcoff, NL;Rosen, BR
通讯作者：
Rosen, BR
DOI：
10.1016/s0065-2601(08)00404-8
发表时间：
2009-01-01
期刊：
ADVANCES IN EXPERIMENTAL SOCIAL PSYCHOLOGY, VOL 41
影响因子：
--
作者：
Barrett, Lisa Feldman;Bliss-Moreau, Eliza
通讯作者：
Bliss-Moreau, Eliza
影响因子：
3.2
作者：
Buckner, RL;Snyder, AZ;Morris, JC
通讯作者：
Morris, JC
影响因子：
1.9
作者：
Burns, LH;Annett, L;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
64.8
作者：
Anderson, AK;Phelps, EA
通讯作者：
Phelps, EA