Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United States.
Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United States.
复制标题
DOI：
10.1016/j.scitotenv.2012.06.098
复制
发表时间：
2012-09-01
期刊：
影响因子：
--
通讯作者：
Ward MH
中科院分区：
文献类型：
--
作者：
Deziel NC;Nuckols JR;Colt JS;De Roos AJ;Pronk A;Gourley C;Severson RK;Cozen W;Cerhan JR;Hartge P;Ward MH
美国家庭粉尘中多氯二苯并对二恶英和多氯二苯并呋喃(PCDD/F)水平的决定因素尚未得到很好的表征。我们进行了一项试验性研究，以评估房屋粉尘中的PCDD/F浓度与住宅与已知污染源(包括工业设施和交通)的接近程度之间的关系。来自底特律、洛杉矶、西雅图或爱荷华州40名居民家中的真空袋粉尘样本，在1998-2000年间参与了一项基于人群的非霍奇金淋巴瘤病例对照研究，使用高分辨率气相色谱/高分辨率质谱仪对美国环境保护局(EPA)认为有毒的7种PCDD和10种PCDF同系物进行了分析。从环保局获得了10种类型的多氯二苯并二恶英/氟化物排放设施的位置；但只有4种类型位于研究房屋附近(无害性废物水泥窑、燃煤发电厂、污水污泥焚烧炉和医疗废物焚烧炉)。使用针对每个同类的单独的多变量回归模型来评估每种多氯二恶英/氟的浓度与工业设施、货运路线和主要道路的接近程度之间的关系。这些同系物在室内粉尘中的中位数(四分位数范围[IQR])毒性当量(TEQ)浓度为20.3pg/g(IQR=14.3，32.7)。在距水泥窑3或5公里范围内的家庭中，5-二恶英和5-多氯二苯并呋喃的浓度要高出2到9倍(每种型号均为0.1)。靠近货运路线和主要道路与1种多氯二苯并二恶英和8种多氯二苯并呋喃的浓度升高有关。在水泥窑、货运路线和主要道路附近的家庭中，某些二恶英/氟的浓度较高，这表明这些室外来源正在导致室内环境暴露。有必要进一步研究这些来源和其他设施类型在更多家庭中对多氯二苯并二恶英/氟化物总暴露的贡献。
Determinants of levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) in dust in U.S. homes are not well characterized. We conducted a pilot study to evaluate the relationship between concentrations of PCDD/F in house dust and residential proximity to known sources, including industrial facilities and traffic. Samples from vacuum bag dust from homes of 40 residents of Detroit, Los Angeles, Seattle, or Iowa who participated in a population-based case-control study of non-Hodgkin lymphoma conducted in 1998–2000 were analyzed using high resolution gas chromatography/high resolution mass spectrometry for 7 PCDD and 10 PCDF congeners considered toxic by the U.S. Environmental Protection Agency (EPA). Locations of 10 types of PCDD/F-emitting facilities were obtained from the EPA; however only 4 types were located near study homes (non-hazardous waste cement kilns, coal-fired power plants, sewage sludge incinerators, and medical waste incinerators). Relationships between concentrations of each PCDD/F and proximity to industrial facilities, freight routes, and major roads were evaluated using separate multivariate regression models for each congener. The median (inter-quartile range [IQR]) toxic equivalence (TEQ) concentration of these congeners in the house dust was 20.3 pg/g (IQR=14.3, 32.7). Homes within 3 or 5 km of a cement kiln had 2 to 9-fold higher concentrations of 5 PCDD and 5 PCDF (p<0.1 in each model). Proximity to freight routes and major roads was associated with elevated concentrations of 1 PCDD and 8 PCDF. Higher concentrations of certain PCDD/F in homes near cement kilns, freight routes, and major roads suggest these outdoor sources are contributing to indoor environmental exposures. Further study of the contribution of these sources and other facility types to total PCDD/F exposure in a larger number of homes is warranted.
登录
查看更多内容
影响因子：
10.4
作者：
Lubin JH;Colt JS;Camann D;Davis S;Cerhan JR;Severson RK;Bernstein L;Hartge P
通讯作者：
Hartge P
DOI：
10.1038/sj.jea.7500307
发表时间：
2004-01-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Colt, JS;Lubin, J;Hartge, P
通讯作者：
Hartge, P
影响因子：
5.4
作者：
Floret, N;Mauny, F;Viel, JF
通讯作者：
Viel, JF
DOI：
10.1080/15459620802694975
发表时间：
2009-01-01
影响因子：
2
作者：
Franzblau, Alfred;Zwica, Lynn;Towey, Tim
通讯作者：
Towey, Tim
影响因子：
5
作者：
Ilacqua, V;Freeman, NCJ;Lioy, PJ
通讯作者：
Lioy, PJ