Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma.
Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma.
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DOI：
10.1186/s12885-015-1115-2
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发表时间：
2015-03-14
期刊：
影响因子：
3.8
通讯作者：
Byers T
中科院分区：
文献类型：
--
作者：
Henry CJ;Sedjo RL;Rozhok A;Salstrom J;Ahnen D;Levin TR;D'Agostino R Jr;Haffner S;DeGregori J;Byers T
结肠微环境中的炎性细胞因子已显示随着结肠直肠癌疾病状态的进展而增加。然而，炎性细胞因子对癌前病变（如腺瘤形成）的作用尚不清楚。使用Milliplex® MAP人类细胞因子/趋化因子磁珠板免疫测定法，在参加NCI-funded胰岛素抵抗性动脉粥样硬化结肠研究的无腺瘤参与者（n = 97）和具有腺瘤的参与者（n = 97）中测定血清细胞因子和趋化因子谱。白细胞介素-10（IL-10）、IL-1β、IL-6、IL-17 A、IL-2、IL-4、IL-7、IL-12（p70）、干扰素-γ（IFN-γ）、巨噬细胞趋化蛋白-1（MCP-1）、活化调节、正常T细胞表达和分泌（RANTES）、肿瘤坏死因子-α（TNF-α）、血管内皮生长因子（VEGF）、测定粒细胞巨噬细胞集落刺激因子（GM-CSF）、巨噬细胞炎性蛋白-1 β（MIP-1β）。多元逻辑回归分析用于评估腺瘤患病率和细胞因子水平之间的关系。结直肠腺瘤的存在与促炎性（TNF-α、IL-6、IL-1β）或T细胞极化（IL-12、IL-2、IL-10、IL-4、IL-17、IFN-γ）细胞因子的全身水平显著升高无关。此外，MCP-1和RANTES水平在有和没有腺瘤的研究参与者的血清中是相等的。这些发现表明结直肠腺瘤的患病率可能与全身炎症的显著变化无关。
Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, such as the formation of adenomas, is unclear. Using the Milliplex® MAP Human Cytokine/ Chemokine Magnetic Bead Panel Immunoassay, serum cytokine and chemokine profiles were assayed among participants without an adenoma (n = 97) and those with an adenoma (n = 97) enrolled in the NCI-funded Insulin Resistance Atherosclerosis Colon Study. The concentrations of interleukin-10 (IL-10), IL-1β, IL-6, IL-17A, IL-2, IL-4, IL-7, IL-12(p70), interferon-γ (IFN-γ), macrophage chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted (RANTES), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), granulocyte macrophage colony-stimulating factor (GM-CSF), and macrophage inflammatory protein-1β (MIP-1β) were determined. Multiple logistic regression analyses were used to evaluate the association between adenoma prevalence and cytokine levels. The presence of colorectal adenomas was not associated with significant increases in the systemic levels of proinflammatory (TNF-α, IL-6, IL-1β) or T-cell polarizing (IL-12, IL-2, IL-10, IL-4, IL-17, IFN-γ) cytokines. Furthermore, MCP-1 and RANTES levels were equivalent in the serum of study participants with and without adenomas. These findings suggest colorectal adenoma prevalence may not be associated with significant alterations in systemic inflammation.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
4.6
作者：
Parkitny L;McAuley JH;Kelly PJ;Di Pietro F;Cameron B;Moseley GL
通讯作者：
Moseley GL
DOI：
10.1158/1940-6207.capr-09-0161
发表时间：
2010-06
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Bobe G;Albert PS;Sansbury LB;Lanza E;Schatzkin A;Colburn NH;Cross AJ
通讯作者：
Cross AJ
影响因子：
9.7
作者：
Krzystek-Korpacka, Malgorzata;Diakowska, Dorota;Gamian, Andrzej
通讯作者：
Gamian, Andrzej
影响因子：
24.5
作者：
Atkin, WS;Saunders, BP
通讯作者：
Saunders, BP