Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.
复制标题
DOI：
10.1289/ehp.0901518
复制
发表时间：
2010-06
影响因子：
10.4
通讯作者：
Alavanja MC
中科院分区：
文献类型：
--
作者：
Dennis LK;Lynch CF;Sandler DP;Alavanja MC
黑色素瘤发病率继续增加;然而，除了阳光敏感性和紫外线辐射（包括阳光照射）之外，几乎没有发现其他风险因素。尽管对农民的研究表明，他们患黑色素瘤和其他皮肤癌的风险过高，但与其他农业暴露相比，目前还不清楚这与阳光照射有多大关系。我们研究了50种农业杀虫剂的剂量反应关系，以及沿着使用含砷的旧杀虫剂的农业健康研究队列中的持牌农药施用者皮肤黑色素瘤发病率。采用逻辑回归分析来检查与农药暴露相关的比值比（OR）和95%置信区间（CI），并对年龄、性别和其他潜在混杂因素进行了调整。我们发现皮肤黑色素瘤和代森锰锌/代森锰锌（63个暴露日：OR = 2.4; 95% CI，1.2-4.9;趋势p = 0.006），（≥ 56暴露日：OR = 2.4; 95% CI，1.3-4.4;趋势p = 0.003）和西维因（≥ 56暴露日：OR = 1.7; 95% CI，1.1-2.5;趋势p = 0.013）。还提出了与苯菌灵和曾经使用含砷农药的其他联系。大多数以前的黑色素瘤文献集中在宿主因素和阳光照射。我们的研究显示了几种农药和黑色素瘤之间的关联，为农业化学品可能是黑色素瘤风险的另一个重要来源的假设提供了支持。
Melanoma rates continue to increase; however, few risk factors other than sun sensitivity and ultraviolet radiation (including sun exposure) have been identified. Although studies of farmers have shown an excess risk of melanoma and other skin cancers, it is unclear how much of this is related to sun exposure compared with other agricultural exposures. We examined dose–response relationships for 50 agricultural pesticides and cutaneous melanoma incidence in the Agricultural Health Study cohort of licensed pesticide applicators, along with ever use of older pesticides that contain arsenic. Logistic regression was used to examine odds ratios (ORs) and 95% confidence intervals (CIs) associated with pesticide exposure adjusted for age, sex, and other potential confounders. We found significant associations between cutaneous melanoma and maneb/mancozeb (63 exposure days: OR = 2.4; 95% CI, 1.2–4.9; trend p = 0.006), parathion (≥ 56 exposure days: OR = 2.4; 95% CI, 1.3–4.4; trend p = 0.003), and carbaryl (≥ 56 exposure days: OR = 1.7; 95% CI, 1.1–2.5; trend p = 0.013). Other associations with benomyl and ever use of arsenical pesticides were also suggested. Most previous melanoma literature has focused on host factors and sun exposure. Our research shows an association between several pesticides and melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of melanoma risk.
登录
查看更多内容
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
6.4
作者：
Mahajan, Rajeev;Blair, Aaron;Alavanja, Michael C. R.
通讯作者：
Alavanja, Michael C. R.
影响因子：
8.8
作者：
Hsueh, Y M;Cheng, G S;Wu, M M;Yu, H S;Kuo, T L;Chen, C J
通讯作者：
Chen, C J
影响因子：
10.4
作者：
Blair, A;Zahm, SH
通讯作者：
Zahm, SH
DOI：
10.1097/01.jom.0000111603.84316.0f
发表时间：
2004-02-01
影响因子：
3.2
作者：
Akhtar, FZ;Garabrant, DH;Michalek, JE
通讯作者：
Michalek, JE