The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity.
The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity.
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DOI：
10.1016/j.mce.2012.01.001
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发表时间：
2012-05-06
影响因子：
4.1
通讯作者：
Taylor, Julia A.
中科院分区：
文献类型：
--
作者：
Saal, Frederick S. vom;Nagel, Susan C.;Coe, Benjamin L.;Angle, Brittany M.;Taylor, Julia A.
越来越多的实验和流行病学证据表明，遗传系统的胎儿编程是最近成人肥胖和代谢综合征其他成分增加的一个促成因素。特别是，有证据表明，与使用人造化学品相关的表观遗传变化可能与影响胎儿和产后生长的其他因素相互作用，导致目前的肥胖流行病。本综述的重点是雌激素性内分泌干扰物（EDCs）的发育影响，更具体地说，暴露于雌激素性EDCs双酚A（BPA）对脂肪细胞及其功能的影响，以及对成人肥胖的最终影响; BPA暴露也会导致生殖能力受损。我们讨论了内分泌干扰物与其他影响胎儿和新生儿生长的因素的相互作用，如胎盘血流量和胎儿营养转运，以及这些因素如何影响胎儿生长和维持正常体重所需的稳态控制系统的异常。
There is increasing experimental and epidemiological evidence that fetal programming of genetic systems is a contributing factor in the recent increase in adult obesity and other components of metabolic syndrome. In particular, there is evidence that epigenetic changes associated with the use of manmade chemicals may interact with other factors that influence fetal and postnatal growth in contributing to the current obesity epidemic. The focus of this review is on the developmental effects of estrogenic endocrine disrupting chemicals (EDCs), and more specifically on effects of exposure to the estrogenic EDC bisphenol A (BPA), on adipocytes and their function, and the ultimate impact on adult obesity; BPA exposure also results in impaired reproductive capacity. We discuss the interaction of EDCs with other factors that impact growth during fetal and neonatal life, such as placental blood flow and nutrient transport to fetuses, and how these influence fetal growth and abnormalities in homeostatic control systems required to maintain normal body weight throughout life.
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
影响因子：
4.1
作者：
Ben-Jonathan N;Hugo ER;Brandebourg TD
通讯作者：
Brandebourg TD
DOI：
10.1080/07315724.2004.10719428
发表时间：
2004-12-01
影响因子：
3.5
作者：
Barker, DJP
通讯作者：
Barker, DJP
影响因子：
10.4
作者：
Alonso-Magdalena P;Morimoto S;Ripoll C;Fuentes E;Nadal A
通讯作者：
Nadal A