Hyperuricemia and risk of stroke: a systematic review and meta-analysis.
Hyperuricemia and risk of stroke: a systematic review and meta-analysis.
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DOI：
10.1002/art.24612
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发表时间：
2009-07-15
影响因子：
--
通讯作者：
Albert, Daniel A.
中科院分区：
文献类型：
--
作者：
Kim, Seo Young;Guevara, James P.;Kim, Kyoung Mi;Choi, Hyon K.;Heitjan, Daniel F.;Albert, Daniel A.
高尿酸血症被假设为中风和其他心血管疾病的危险因素，但迄今为止，观察性研究的结果是相互矛盾的。我们进行了一项系统回顾和荟萃分析，以评估高尿酸血症与卒中发病率和死亡率风险之间的关系。通过使用医学主题词和关键词检索主要电子数据库来识别研究，不受语言限制。只有前瞻性队列研究，如果他们有数据的中风发病率或死亡率相关的血清尿酸水平的成年人。计算卒中发病率和死亡率与血清尿酸水平相关的合并风险比（RR）。共有16项研究（包括238，449名成人）符合条件并进行了摘要。在我们对未调整研究估计值的荟萃分析中，高尿酸血症与中风发生率[N=6项研究，RR 1.41，95%置信区间（CI）：1.05-1.76]和死亡率[N=6项研究，RR 1.36，95%CI：1.03-1.69]的风险显着升高相关。调整已知风险因素（如年龄、高血压、糖尿病和胆固醇）的研究亚组分析仍显示，高尿酸血症与卒中发生率[N=4项研究，RR 1.47，95% CI：1.19-1.76]和死亡率[N=6项研究，RR 1.26，95% CI：1.12-1.39]显著相关。多变量RR的汇总估计值在性别之间没有太大差异。我们的研究表明，高尿酸血症可能适度增加中风的发病率和死亡率的风险。未来的研究需要确定降低尿酸水平是否对中风有任何有益的影响。
Hyperuricemia is hypothesized to be a risk factor for stroke and other cardiovascular disease, but to date results from observational studies are conflicting. We conducted a systematic review and meta-analysis to assess the association between hyperuricemia and risk of stroke incidence and mortality. Studies were identified by searching major electronic databases using the Medical Subject Headings and keywords without restriction in languages. Only prospective cohort studies were included if they had data on stroke incidences or mortalities related to serum uric acid levels in adults. Pooled risk ratios (RRs) for the association of stroke incidence and mortality with serum uric acid levels were calculated. A total of 16 studies including 238,449 adults were eligible and abstracted. Hyperuricemia was associated with a significantly higher risk of both stroke incidence [N=6 studies, RR 1.41, 95% confidence interval (CI): 1.05–1.76] and mortality [N=6 studies, RR 1.36, 95% CI: 1.03–1.69] in our meta-analyses of unadjusted study estimates. Subgroup analyses of studies adjusting for known risk factors such as age, hypertension, diabetes, and cholesterol still showed that hyperuricemia was significantly associated with both stroke incidence [N=4 studies, RR 1.47, 95% CI: 1.19–1.76] and mortality [N=6 studies, RR 1.26, 95% CI: 1.12–1.39]. The pooled estimate of multivariate RRs did not differ much by gender. Our study suggests that hyperuricemia may modestly increase the risks of both stroke incidence and mortality. Future research is needed to determine whether lowering uric acid level has any beneficial effects on stroke.
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影响因子：
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