Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.
Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis.
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DOI：
10.1016/j.cortex.2015.03.021
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发表时间：
2015-06
期刊：
影响因子：
3.6
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Fletcher, Philip D.;Downey, Laura E.;Golden, Hannah L.;Clark, Camilla N.;Slattery, Catherine F.;Paterson, Ross W.;Schott, Jonathan M.;Rohrer, Jonathan D.;Rossor, Martin N.;Warren, Jason D.
关键词：
痴呆症患者可能会对环境声音和音乐表现出异常改变的喜好，但这种改变的听觉享乐反应尚未得到系统研究。在这里，我们使用半结构化看护者行为问卷和患者大脑 MR 图像的基于体素的形态测量 (VBM)，在代表主要典型痴呆综合征（行为变异型额颞叶痴呆 (bvFTD)、语义痴呆 (SD)、进行性非流利性失语症 (PNFA) 遗忘性阿尔茨海默病 (AD)）的 73 名患者队列中解决了这个问题。大约一半的队列中出现了对环境声音异常厌恶、对音乐厌恶或对音乐的高度愉悦（“音乐癖”）的行为反应，但显示出明显的综合征和基因分离，发生在大多数 bvFTD 患者中，但在 PNFA 中不常见，与 MAPT 相关而不是与 C9orf72 突变相关。对声音的厌恶是 AD 中唯一的听觉表型，而包括音乐癖在内的更复杂的表型在 bvFTD 和 SD 中很常见。听觉享乐的改变与灰质损失相关，该灰质损失存在于一个共同的、分布式的、右侧化的网络中，包括前内侧颞叶、岛叶、前扣带回和伏隔核。我们的研究结果表明，听觉享乐处理异常是常见痴呆症的一个重要问题。声音可能构成一种新的探针，用于研究神经退行性疾病针对的情绪显着性编码的大脑机制。
Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music (‘musicophilia’) occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.
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影响因子：
4.8
作者：
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影响因子：
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作者：
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Warren, Jason D.
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Goll JC;Kim LG;Hailstone JC;Lehmann M;Buckley A;Crutch SJ;Warren JD
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Warren JD
DOI：
10.1073/pnas.191355898
发表时间：
2001-09-25
影响因子：
11.1
作者：
Blood, AJ;Zatorre, RJ
通讯作者：
Zatorre, RJ