Endocrine disruptors and asthma-associated chemicals in consumer products.
Endocrine disruptors and asthma-associated chemicals in consumer products.
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DOI：
10.1289/ehp.1104052
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发表时间：
2012-07
影响因子：
10.4
通讯作者：
Rudel RA
中科院分区：
文献类型：
--
作者：
Dodson RE;Nishioka M;Standley LJ;Perovich LJ;Brody JG;Rudel RA
背景资料：实验室和人体研究引起了人们对接触消费品中的化学品导致内分泌紊乱和哮喘的关注。有限的标签或测试信息可用于评估作为暴露源的产品。目的：我们对一系列化妆品、个人护理产品、清洁剂、防晒霜和乙烯基产品中的内分泌干扰物和哮喘相关化学物质进行了分析量化。我们还评估了产品标签是否提供了可用于选择不含这些化学物质的产品的信息。方法：我们选择了代表50种产品类型的213种商业产品。我们测试了42种高市场份额产品的复合样品，并测试了43种替代产品，这些替代产品使用预期最大限度地减少目标化合物的标准来确定。分析物包括对羟基苯甲酸酯、邻苯二甲酸酯、双酚A（BPA）、三氯生、乙醇胺、烷基酚、香料、乙二醇醚、环硅氧烷和紫外线（UV）过滤剂。结果：我们检测到55种化合物，表明来自常见产品的广泛暴露。乙烯基产品含有> 10%的邻苯二甲酸二（2-乙基己基）酯（DEHP），可能是家庭中DEHP的重要来源。在其他产品中，最高浓度和检测数量是在芳香产品中（例如，香水、空气清新剂和干燥剂）和防晒剂中。一些不含众所周知的干扰内分泌的邻苯二甲酸酯的产品含有其他研究较少的邻苯二甲酸酯（邻苯二甲酸二环己酯、邻苯二甲酸二异壬酯和邻苯二甲酸二正丙酯;也是干扰内分泌的化合物），这表明存在替代品。许多检测到的化学物质没有在产品标签上列出。结论：普通产品含有内分泌干扰物和哮喘相关化合物的复杂混合物。需要对这些混合物进行毒理学研究，以了解其生物活性。关于流行病学，我们的研究结果引起了人们对共存化学品的潜在混淆和由于产品成分的变化而导致的错误分类的担忧。消费者应该能够避免一些目标化学品合成香料，双酚A和受管制的活性成分使用购买标准。更完整的产品标签将使消费者能够避免其他目标化学品。
Background: Laboratory and human studies raise concerns about endocrine disruption and asthma resulting from exposure to chemicals in consumer products. Limited labeling or testing information is available to evaluate products as exposure sources. Objectives: We analytically quantified endocrine disruptors and asthma-related chemicals in a range of cosmetics, personal care products, cleaners, sunscreens, and vinyl products. We also evaluated whether product labels provide information that can be used to select products without these chemicals. Methods: We selected 213 commercial products representing 50 product types. We tested 42 composited samples of high-market-share products, and we tested 43 alternative products identified using criteria expected to minimize target compounds. Analytes included parabens, phthalates, bisphenol A (BPA), triclosan, ethanolamines, alkylphenols, fragrances, glycol ethers, cyclosiloxanes, and ultraviolet (UV) filters. Results: We detected 55 compounds, indicating a wide range of exposures from common products. Vinyl products contained > 10% bis(2-ethylhexyl) phthalate (DEHP) and could be an important source of DEHP in homes. In other products, the highest concentrations and numbers of detects were in the fragranced products (e.g., perfume, air fresheners, and dryer sheets) and in sunscreens. Some products that did not contain the well-known endocrine-disrupting phthalates contained other less-studied phthalates (dicyclohexyl phthalate, diisononyl phthalate, and di-n-propyl phthalate; also endocrine-disrupting compounds), suggesting a substitution. Many detected chemicals were not listed on product labels. Conclusions: Common products contain complex mixtures of EDCs and asthma-related compounds. Toxicological studies of these mixtures are needed to understand their biological activity. Regarding epidemiology, our findings raise concern about potential confounding from co-occurring chemicals and misclassification due to variability in product composition. Consumers should be able to avoid some target chemicals—synthetic fragrances, BPA, and regulated active ingredients—using purchasing criteria. More complete product labeling would enable consumers to avoid the rest of the target chemicals.
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影响因子：
10.4
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
通讯作者：
Needham LL
影响因子：
5
作者：
Dodson, Robin E.;Levy, Jonathan I.;Bennett, Deborah H.
通讯作者：
Bennett, Deborah H.
影响因子：
--
作者：
Bornehag, C. G.;Nanberg, E.
通讯作者：
Nanberg, E.
影响因子：
11.1
作者：
Dunagan, Sarah C.;Dodson, Robin E.;Brody, Julia G.
通讯作者：
Brody, Julia G.
影响因子：
10.4
作者：
Bornehag CG;Sundell J;Weschler CJ;Sigsgaard T;Lundgren B;Hasselgren M;Hägerhed-Engman L
通讯作者：
Hägerhed-Engman L