Changes in Antibiotic Prescription After Tooth Extraction: A Population-Based Study from 2002 to 2018.
Changes in Antibiotic Prescription After Tooth Extraction: A Population-Based Study from 2002 to 2018.
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DOI：
10.1016/j.identj.2021.01.010
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发表时间：
2021-12
影响因子：
3.3
通讯作者：
Lee, Kyeong Hee
中科院分区：
文献类型：
--
作者：
Choi, Yoon Young;Lee, Kyeong Hee
关键词：
抗生素滥用导致的微生物耐药性是一个世界性问题。本研究旨在研究韩国拔牙后抗生素处方的趋势。从国民健康保险共享服务数据库中，选取2002年至2018年拔牙的患者为研究对象，通过性别和年龄分层抽样，抽取其中10%的患者。总体而言，观察到年度抗生素处方和广谱抗生素处方模式的病例为15，838，529例。此外，使用规定的每日剂量计算标准化的年度抗生素使用量。在13，429，770例（84.8%）拔牙病例中开具了处方，其中12，179，185例（90.7%）包括抗生素。Logistic回归分析显示，与2002年相比，2003年拔牙后处方抗生素的可能性有所下降（比值比为0.95），但从2004年到2018年有所增加。在广谱抗生素处方率的情况下，2002年至2012年之间没有明显的趋势（比值比，0.89-1.07）;然而，在过去5年中，广谱抗生素处方的可能性稳步增加。根据每天1000名患者的限定日剂量计算，抗生素的价值在2002年为4.39，随后稳步上升，2018年达到6.97，而广谱抗生素的价值在2002年为1.68，此后一直在上升; 2018年最高为3.82。拔牙后抗生素的使用在过去17年中有所增加;此外，在过去5年中，广谱抗生素的处方率也有所增加。
Microbial resistance due to antibiotic misuse is a worldwide problem. This study aimed to examine the trends in antibiotic prescription after tooth extraction in Korea. From the database of National Health Insurance Sharing Service, patients who underwent tooth extraction from 2002 to 2018 were selected as subjects, and 10% of them were selected via stratified sampling based on sex and age. Overall, 15,838,529 cases were observed for annual antibiotic prescription and broad-spectrum antibiotic prescription patterns. Additionally, standardized annual antibiotic use was calculated using a defined daily dose. Prescriptions were issued in 13,429,770 (84.8%) of the tooth extraction cases, of which 12,179,185 (90.7%) included antibiotics. Logistic regression analysis revealed that the likelihood of prescribing antibiotics after tooth extraction decreased in 2003 compared to 2002 (odds ratio, 0.95) but increased from 2004 to 2018. In the case of the broad-spectrum antibiotic prescription rate, there was no clear trend between 2002 and 2012 (odds ratio, 0.89-1.07); however, over the last 5 years, the likelihood of broad-spectrum antibiotic prescription has steadily increased. The value of antibiotics based on the defined daily dose of 1000 patients per day was calculated to be 4.39 in 2002, exhibiting a steady increase later and reaching 6.97 in 2018, whereas that of broad-spectrum antibiotics was 1.68 in 2002 and has since been on the rise; the highest was 3.82 in 2018. Antibiotic use after tooth extraction increased over the last 17 years; additionally, the rate of prescribing broad-spectrum antibiotics has increased over the last 5 years.
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影响因子：
3.9
作者：
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通讯作者：
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