Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso.
Additional selection for insecticide resistance in urban malaria vectors: DDT resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso.
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DOI：
10.1371/journal.pone.0045995
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ranson H
中科院分区：
文献类型：
--
作者：
Jones CM;Toé HK;Sanou A;Namountougou M;Hughes A;Diabaté A;Dabiré R;Simard F;Ranson H
在布基纳法索的博博迪乌拉索市，阿拉伯按蚊已经取代了冈比亚按蚊。因为主要的疟疾媒介和幼虫存在于通常被认为不适合按蚊生存的高度污染的栖息地。这里我们展示的是 An.冈比亚有限公司来自市中心高度污染地点（迪乌拉索巴）的成年人对滴滴涕的耐药率很高（接触诊断剂量后的死亡率在旱季和雨季分别为 65.8% 和 70.4%）。对相关机制的调查发现，1014S kdr 突变的频率出乎意料地高（等位基因频率 = 0.4），而在 An 中发现的频率非常低。周边农村地区的阿拉伯树，以及一些解毒基因的转录水平增加，特别是谷胱甘肽转移酶和细胞色素 P450 基因家族。许多 ABC 转运蛋白基因在 DDT 抗性 An 中也以升高的水平表达。阿拉伯。无计划的城市化为蚊子提供了众多滋生地。适应这些城市繁殖地的按蚊具有很高的杀虫剂抗药性，这一发现对于我们了解导致非洲疟疾病媒抗杀虫剂种群快速传播的选择性力量具有重要意义。
In the city of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded Anopheles gambiae s.s. as the major malaria vector and the larvae are found in highly polluted habitats normally considered unsuitable for Anopheles mosquitoes. Here we show that An. gambiae s.l. adults emerging from a highly polluted site in the city centre (Dioulassoba) have a high prevalence of DDT resistance (percentage mortality after exposure to diagnostic dose = 65.8% in the dry season and 70.4% in the rainy season, respectively). An investigation into the mechanisms responsible found an unexpectedly high frequency of the 1014S kdr mutation (allele frequency = 0.4), which is found at very low frequencies in An. arabiensis in the surrounding rural areas, and an increase in transcript levels of several detoxification genes, notably from the glutathione transferase and cytochrome P450 gene families. A number of ABC transporter genes were also expressed at elevated levels in the DDT resistant An. arabiensis. Unplanned urbanisation provides numerous breeding grounds for mosquitoes. The finding that Anopheles mosquitoes adapted to these urban breeding sites have a high prevalence of insecticide resistance has important implications for our understanding of the selective forces responsible for the rapid spread of insecticide resistant populations of malaria vectors in Africa.
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影响因子：
4.5
作者：
Gahan LJ;Pauchet Y;Vogel H;Heckel DG
通讯作者：
Heckel DG
影响因子：
3.8
作者：
Burton, Mark J.;Mellor, Ian R.;Williamson, Martin S.
通讯作者：
Williamson, Martin S.
影响因子：
3
作者：
Fournet, Florence;Cussac, Maud;Dabire, Roch K.
通讯作者：
Dabire, Roch K.
影响因子：
3.8
作者：
della Torre, A;Tu, ZJ;Petrarca, V
通讯作者：
Petrarca, V
影响因子：
1.9
作者：
Djogbenou, L.;Pasteur, N.;Chandre, F.
通讯作者：
Chandre, F.