Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus.
Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus.
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DOI：
10.1016/j.cub.2009.03.051
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发表时间：
2009-05-26
期刊：
影响因子：
--
通讯作者：
de la Iglesia HO
中科院分区：
文献类型：
--
作者：
Lee ML;Swanson BE;de la Iglesia HO
In near all animals, sleep is consistently concentrated to a specific time of the day. The timing and consolidation of sleep and wake bouts depend on the interplay between a homeostatic and a circadian processes of sleep regulation. Sleep propensity rises as a homeostatic response to increasing wake time while a circadian clock determines the specific time when sleep will likely occur. This two-process regulation of sleep also determines which specific sleep stage will be manifested and specifically, the circadian process governs tightly the manifestation of rapid eye movement sleep (REMS). The role of the hypothalamic suprachiasmatic nucleus (SCN) in the circadian gating of sleep and wakefulness has been unequivocally established by lesion studies but its role in the timing of specific sleep stages has remained unknown. Using a forced desynchrony paradigm that induces the stable uncoupling of the ventrolateral (vl) and dorsomedial (dm) SCN, and a jetlag paradigm that induces a transient desynchronization between these SCN subregions we provide evidence that the SCN can time the occurrence of specific sleep stages. Specifically, the circadian regulation of REMS is associated with rhythmic clock gene expression within the dmSCN. Our results also provide the first neurophysiological model for the disruptions of sleep architecture that may result from temporal challenges such as rotational shift-work and transmeridional flights.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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9.2
作者：
de la Iglesia, HO;Cambras, T;Díez-Noguera, A
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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