Maternal exercise and its beneficial effects on glucose metabolism in offspring
Maternal exercise and its beneficial effects on glucose metabolism in offspring
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母亲运动及其对后代葡萄糖代谢的有益影响
DOI：
10.1097/cm9.0000000000000731
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发表时间：
2020-03
影响因子：
6.1
通讯作者：
Xin-Hua Xiao
中科院分区：
文献类型：
--
作者：
Jia Zheng;Li-Yuan Zhou;Xin-Hua Xiao
摘要研究表明，母亲的有害暴露和条件可能导致后代肥胖和2型糖尿病的发生。这可能导致代谢功能障碍的恶性循环，其中育龄个体的肥胖、糖尿病前期和糖尿病的发病率上升，将风险传播给后代。众所周知，经常锻炼对肥胖和2型糖尿病患者有重要的健康益处。近年来，越来越多的研究旨在探讨母亲运动对后代代谢健康的影响。本文综述了母亲在发育关键期的运动及其对后代葡萄糖代谢的影响，包括干预时机，性别二型性，不同的运动类型和强度。然后，我们进一步研究表观遗传修饰在这一过程中的潜在作用。
Abstract It shows that detrimental exposures and conditions in mothers can lead to the development of obesity and type 2 diabetes in offspring. This can lead to a vicious cycle of metabolic dysfunction, where rising rates of obesity, pre-diabetes, and diabetes in individuals of reproductive age, propagating risks to subsequent generations. It is well established that regular exercise has important health benefits for people with obesity and type 2 diabetes. Recently, increasing studies aim to examine the effects of maternal exercise on metabolic health in offspring. This review aims to demonstrate the evidence linking maternal exercise during critical periods of development and its implications for glucose metabolism in offspring, including intervention timing, sexual dimorphism, different exercise type, and intensity. Then we further examine the potential role of epigenetic modifications in this process.
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