Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid.
Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid.
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DOI：
10.1155/2013/269787
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发表时间：
2013
影响因子：
4.6
通讯作者：
Semeraro F
中科院分区：
文献类型：
--
作者：
Morescalchi F;Duse S;Gambicorti E;Romano MR;Costagliola C;Semeraro F
眼损伤是一个严重的致残性全球健康问题。增殖性玻璃体视网膜病变（PVR）是一种常见的并发症，可在高达40-60%的开放眼球损伤患者中发生。在过去的几十年里，我们对PVR发病机制的了解有所提高。似乎免疫细胞进入玻璃体，就像穿透性眼外伤一样，会触发生长因子和细胞因子的产生，这些生长因子和细胞因子与视网膜内细胞（如m<s:1> ller细胞和RPE细胞）接触。生长因子和细胞因子驱动细胞反应导致PVR的发展。对创伤后PVR的病理生物学和病理生理机制的了解增加了治疗的可能性，希望在未来我们的治疗策略能够发展，特别是采用多药物治疗方法，并在视力恢复方面变得更加有效。本文综述了目前关于PVR发病机制及其与眼外伤相关性的文献和临床试验数据，并描述了将为开发新的治疗策略奠定基础的生化/分子事件。本文献综述包括1979年至2013年发表的PubMed文章。只包括用英语写的研究。
Eye injury is a significant disabling worldwide health problem. Proliferative Vitreoretinopathy (PVR) is a common complication that develops in up to 40–60% of patients with an open-globe injury. Our knowledge about the pathogenesis of PVR has improved in the last decades. It seems that the introduction of immune cells into the vitreous, like in penetrating ocular trauma, triggers the production of growth factors and cytokines that come in contact with intra-retinal cells, like Müller cells and RPE cells. Growth factors and cytokines drive the cellular responses leading to PVR's development. Knowledge of the pathobiological and pathophysiological mechanisms involved in posttraumatic PVR is increasing the possibilities of management, and it is hoped that in the future our treatment strategies will evolve, in particular adopting a multidrug approach, and become even more effective in vision recovery. This paper reviews the current literature and clinical trial data on the pathogenesis of PVR and its correlation with ocular trauma and describes the biochemical/molecular events that will be fundamental for the development of novel treatment strategies. This literature review included PubMed articles published from 1979 through 2013. Only studies written in English were included.
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影响因子：
--
作者：
CAMPOCHIARO, PA;BRYAN, JA;JACCOMA, EH
通讯作者：
JACCOMA, EH
影响因子：
4.2
作者：
CLEARY, PE;RYAN, SJ
通讯作者：
RYAN, SJ
影响因子：
4.1
作者：
Cassidy, L;Barry, P;Kennedy, S
通讯作者：
Kennedy, S
影响因子：
4.2
作者：
AbuElAsrar, AM;VanDamme, J;Missotten, L
通讯作者：
Missotten, L
影响因子：
3.7
作者：
Ciulla, Thomas A;Walker, Jonathan D;Criswell, Mark H
通讯作者：
Criswell, Mark H