Gene regulation in rodent hepatocytes during development, differentiation and disease.
Gene regulation in rodent hepatocytes during development, differentiation and disease.
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啮齿动物肝细胞在发育、分化和疾病过程中的基因调控。
DOI：
10.1111/j.1432-1033.1993.tb18152.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
J. Mirkovitch
中科院分区：
文献类型：
--
作者：
K. Xanthopoulos;J. Mirkovitch
肝脏中基因的表达主要控制在转录水平，依赖于顺式作用序列和反式作用分子之间的调控相互作用。近端启动子和远端增强子结合大量富含肝细胞的dna结合蛋白和一般转录因子与这些元件特异性相互作用，并控制肝脏特异性基因的表达。从肝核提取物中分离到富集肝细胞的调节蛋白，对其进行了鉴定，并克隆了相应的基因。这些包括肝细胞核因子1,3,4 (hnf -1,3,4)， CAAAT/增强子结合蛋白（C/EBP）家族的一些成员和D位点结合蛋白（DBP）。这些因素属于较大的家族，并且能够与同一家族的其他成员形成异二聚体，也许HNF-3家族除外。有趣的是，大多数编码这些蛋白的基因本身在转录水平上受到调控，尽管转录和转录后事件在发育、肝细胞分化和疾病过程中调节它们的表达，这表明转录级联可能在哺乳动物肝脏发育和分化中发挥关键作用。
The expression of genes in the liver is mostly controlled at the transcriptional level and depends on the regulatory interactions between cis-acting sequences and trans-acting molecules. Proximal promoters and distant enhancers in combination with a number of hepatocyte-enriched DNA-binding proteins and general transcription factors interact specifically with these elements and control the expression of liver-specific genes. Hepatocyte-enriched regulatory proteins have been isolated from liver nuclear extracts, characterized, and their corresponding genes have been cloned. These include the hepatocyte nuclear factors 1, 3, 4 (HNF-1,3,4), some members of the CAAAT/enhancer binding protein (C/EBP) family, and D site binding protein (DBP). These factors belong to larger families and are able to form heterodimers, perhaps with the exception of the HNF-3 family, with other members of the same family. Interestingly, the majority of the genes encoding such proteins are themselves regulated at the transcriptional level, although both transcriptional and post-transcriptional events modulate their expression during development, hepatocyte differentiation and disease, suggesting that a transcriptional cascade may play a critical role in mammalian liver development and differentiation.
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肝再生过程中的基因表达。
影响因子：
5.6
作者：
Friedman,JM;Chung,EY;DarnellJr,JE
通讯作者：
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影响因子：
10.5
作者：
LIN, FT;LANE, MD
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小鼠 DNA 结合蛋白 mC/EBP 的细胞特异性转录控制。
DOI：
10.1073/pnas.86.11.4117
发表时间：
1989
影响因子：
11.1
作者：
Xanthopoulos,KG;Mirkovitch,J;Decker,T;Kuo,CF;DarnellJr,JE
通讯作者：
DarnellJr,JE
DOI：
10.1073/pnas.88.9.3807
发表时间：
1991-05-01
影响因子：
11.1
作者：
XANTHOPOULOS, KG;PREZIOSO, VR;DARNELL, JE
通讯作者：
DARNELL, JE
影响因子：
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作者：
MENDEL, DB;HANSEN, LP;CRABTREE, GR
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CRABTREE, GR