Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography.
Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography.
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DOI：
10.1371/journal.pone.0205773
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Querques G
中科院分区：
文献类型：
--
作者：
Rabiolo A;Gelormini F;Sacconi R;Cicinelli MV;Triolo G;Bettin P;Nouri-Mahdavi K;Bandello F;Querques G
比较光学相干断层扫描血管成像(OCT-A)图像上不同算法计算的黄斑和乳头周围血管密度值，阐述转换公式，并比较其区分健康眼和患眼的能力。对健康受试者、糖尿病视网膜病变患者和青光眼患者(每组44只眼)进行横断面研究。用已发表的7种算法计算黄斑浅毛细血管丛(SCP)、深毛细血管丛(DCP)和乳头周围放射状毛细血管丛(RCP)的血管密度。对方法的系统差异、诊断特性、可靠性和一致性进行了调查。无论采用何种算法，健眼在所有神经丛中的血管密度值均高于患眼(p<；0.01)。根据所用方法的不同，估计的血管密度在所有神经丛中都有显著差异(p<；0.0001)。方法间信度和符合度大多为差到中等。除DCP的多水平和固定方法之间的转换外，每种方法都有一个转换公式。许多算法之间明显存在着大量系统性的、非恒定的偏差。在所有视网膜神经丛中，没有一种算法在区分患者和健康受试者方面优于其他算法，但最好的算法因所选的神经丛而异。用不同算法计算的血管密度绝对值不能直接互换。健康眼和患眼之间的差异可以通过分析神经丛的不同辨别能力的所有方法来识别。对血管密度的纵向监测应该使用相同的算法。采用血管密度作为结果衡量标准的研究不应依赖外部标准数据库。
To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. Healthy eyes exhibited higher vessel density values in all plexuses compared to diseased eyes regardless of the algorithm used (p<0.01). The estimated vessel densities were significantly different at all the plexuses (p<0.0001) as a function of method used. Inter-method reliability and agreement was mostly poor to moderate. A conversion formula was available for every method, except for the conversion between multilevel and fixed at the DCP. Substantial systemic, non-constant biases were evident between many algorithms. No algorithm outperformed the others for discrimination of patients from healthy subjects in all the retinal plexuses, but the best performing algorithm varied with the selected plexus. Absolute vessel density values calculated with different algorithms are not directly interchangeable. Differences between healthy and affected eyes could be appreciated with all methods with different discriminatory abilities as a function of the plexus analyzed. Longitudinal monitoring of vessel density should be performed with the same algorithm. Studies adopting vessel density as an outcome measure should not rely on external normative databases.
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DOI：
10.3928/23258160-20140909-08
发表时间：
2014-09
期刊：
Ophthalmic surgery, lasers & imaging retina
影响因子：
--
作者：
Huang Y;Zhang Q;Thorell MR;An L;Durbin MK;Laron M;Sharma U;Gregori G;Rosenfeld PJ;Wang RK
通讯作者：
Wang RK
影响因子：
8.1
作者：
Lei, Jianqin;Durbin, Mary K.;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.
影响因子：
1
作者：
Ghassemi, Fariba;Fadakar, Kaveh;Sabour, Siamak
通讯作者：
Sabour, Siamak
影响因子：
4.1
作者：
Parodi, Maurizio Battaglia;Cicinelli, Maria Vittoria;Bandello, Francesco
通讯作者：
Bandello, Francesco
影响因子：
4.4
作者：
Garrity, Sean T.;Iafe, Nicholas A.;Sarraf, David
通讯作者：
Sarraf, David