The subgingival periodontal microbiota of the aging mouth.

The subgingival periodontal microbiota of the aging mouth.
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DOI:
10.1111/prd.12136
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发表时间:
2016-10
影响因子:
18.6
通讯作者:
Faveri M
Faveri M
中科院分区:
医学1区
文献类型:
--
作者:
Feres M;Teles F;Teles R;Figueiredo LC;Faveri M

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不同的机制已经被假设来解释老年人牙周炎患病率和严重程度的增加,包括牙周微生物群的变化。然而,老化对龈下生物膜组成的实际影响仍不清楚。在本文中,我们概述了老年人龈下生物膜的组成以及年龄对口腔微生物组的潜在影响。特别是,这篇综述涵盖了以下主题:(i)老化口腔的口腔微生物群,(ii)年龄和时间对人类口腔微生物群的影响,(iii)炎症和免疫衰老在宿主-口腔微生物群相互作用中的潜在影响,以及(iv)老化口腔微生物群与阿尔茨海默病的关系。最后,为了更广泛地探索衰老对牙周微生物群的潜在影响,我们分析了从大型临床研究中汇编的数据,这些研究评估了牙周健康受试者和牙周炎患者的龈下微生物群,这些患者来自广泛的年龄范围(20-83岁)。这些研究于1999年至2014年在瓜鲁柳斯大学(巴西圣保罗)和福赛斯研究所(美国剑桥)进行。
Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging in the composition of subgingival biofilms remains unclear. In the present article, we provide an overview of the composition of the subgingival biofilm in older adults and the potential effects of age on the oral microbiome. In particular, this review covers the following topics: (i) the oral microbiota of an aging mouth, (ii) the effects of age and time on the human oral microbiome, (iii) the potential impact of inflammaging and immunosenescence in the host-oral microbiota interactions, and (iv) the relationship of the aging oral microbiota and Alzheimer’s disease. Finally, in order to explore in greater breadth the potential effects of aging on the periodontal microbiota, we present analyses of data compiled from large clinical studies that evaluated the subgingival microbiota of periodontally healthy subjects and periodontitis patients from a wide age spectrum (20–83 years old). Those studies were conducted at Guarulhos University (São Paulo, SP, Brazil) and at The Forsyth Institute (Cambridge, USA), from 1999 to 2014.
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