Current concept and residual issues of lipoprotein(a) determination for a cardiovascular risk factor
Current concept and residual issues of lipoprotein(a) determination for a cardiovascular risk factor
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脂蛋白(a)测定心血管危险因素的当前概念和遗留问题
DOI：
10.1111/eci.13700
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发表时间：
2021
影响因子：
5.5
通讯作者：
Harada‐Shiba Mariko
中科院分区：
文献类型：
--
作者：
Yoshida Hiroshi;Hirowatari Yuji;Ogura Masatsune;Harada‐Shiba Mariko
诊断FH的一个重要因素是在Lp(A)升高的个体中Lp(A)的胆固醇含量有一定的贡献，因为Lp(A)-C被合并到临床的低密度脂蛋白-C测量中。Lp(A)-胆固醇[Lp(A)-C]是Lp(A)粒子运输的胆固醇的量，以mg/dL表示。脂蛋白(A)[Lp(A)]发现于1963年，由载脂蛋白(A)[Apo(A)]与低密度脂蛋白(LDL)样颗粒中的载脂蛋白B(ApoB)共价结合而成。1、2在过去的十年中，流行病学、孟德尔随机化和全基因组关联研究已经证实Lp(A)是动脉粥样硬化性心血管疾病(ASCVD)的一个独立的和可能的原因危险因素。3-6然而，Lp(A)的临床重要性尚未确定，因为既缺乏降低Lp(A)治疗的可靠药物，也缺乏明确的证据表明降低Lp(A)水平可以长期降低ASCVD风险。17 Yeang C，Willeit P，Tsimikas S.在诊断家族性高胆固醇血症中脂蛋白(A)、脂蛋白(A)胆固醇和真实低密度脂蛋白-胆固醇之间的相互联系。[摘自文章]欧洲临床调查杂志版权属于Wiley-Blackwell的财产，未经版权所有者明确的书面许可，不得将其内容复制或通过电子邮件发送到多个站点或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对复制品的准确性不作任何保证。用户应参考该材料的原始出版版本，以获取完整摘要。版权适用于所有摘要。
An important confounder in the diagnosis of FH is the certain contribution of the cholesterol content of Lp (a) in individuals with elevated Lp (a) because Lp (a)-C is incorporated into clinical LDL-C measurements. Lp (a)-cholesterol [Lp (a)-C] is the amount of cholesterol trafficked by Lp (a) particles and is expressed as mg/dL. Lipoprotein (a)[Lp (a)], discovered in 1963, is composed of apolipoprotein (a)[Apo (a)] bound covalently to apolipoprotein B (ApoB) of a low-density lipoprotein (LDL)-like particle. 1, 2 Over the past decade, epidemiological, Mendelian randomization and genome-wide association studies have established Lp (a) as an independent and likely causal risk factor for atherosclerotic cardiovascular disease (ASCVD). 3-6 However, the clinical importance of Lp (a) was not defined because of a lack of both reliable medication for Lp (a)-lowering therapy and definite evidence that lowering Lp (a) levels can reduce ASCVD risk for a long time. 17 Yeang C, Willeit P, Tsimikas S. The interconnection between lipoprotein (a), lipoprotein (a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia.[Extracted from the article]Copyright of European Journal of Clinical Investigation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.
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