Corticotropin releasing factor influences aggression and monoamines: modulation of attacks and retreats.
Corticotropin releasing factor influences aggression and monoamines: modulation of attacks and retreats.
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DOI：
10.1016/j.neuroscience.2008.10.014
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发表时间：
2009-01-23
期刊：
影响因子：
3.3
通讯作者：
Summers, C. H.
中科院分区：
文献类型：
--
作者：
Carpenter, R. E.;Korzan, W. J.;Bockholt, C.;Watt, M. J.;Forster, G. L.;Renner, K. J.;Summers, C. H.
鲑鱼建立社会等级作为侵略性的社会互动的结果。支配或从属地位的建立与通过应激轴介导的神经内分泌反应密切相关。在这项研究中，我们测试了icv CRF的行为结果，血浆皮质醇和单胺功能的鳟鱼受到社会攻击的遭遇。用icv注射人工脑脊液（aCSF）、500或2000 ng绵羊CRF或不注射处理虹鳟鱼。鱼被允许与类似大小的同种相互作用15分钟。在行为相互作用之后，分析血浆皮质醇和中枢单胺浓度。用CRF处理的鳟鱼在与aCSF处理的对手的大约60%的攻击性遭遇中获胜。注射CRF的鳟鱼表现出攻击总数的减少和攻击潜伏期的减少。当鳟鱼分为赢家和输家，只有胜利的CRF治疗的鱼表现出减少潜伏期的攻击和更少的撤退。社会压力增加皮质醇水平的赢家和输家的侵略性互动。icv注射aCSF引起的额外应激增强了这种作用。然而，除了社会压力外，icv CRF还降低了获胜者和失败者的血浆皮质醇。虽然侵略刺激显着的变化，肾上腺素能和多巴胺能的活动，幅度和方向依赖于边缘脑区，CRF剂量，和社会侵略的结果。CRF对攻击性行为、焦虑、应激反应和中枢单胺能活动具有广泛的影响，在调节社会交往的行为成分中起重要作用。
Salmonids establish social hierarchies as a result of aggressive social interactions. The establishment of dominant or subordinate status is strongly linked to neuroendocrine responses mediated through the stress axis. In this study, we tested the effects of icv CRF on the behavioral outcome, plasma cortisol and monoamine function in trout subjected to a socially aggressive encounter. Rainbow trout were treated with an icv injection of artificial cerebrospinal fluid (aCSF), 500 or 2000 ng ovine CRF, or not injected. Fish were allowed to interact with a similarly sized conspecific for 15 minutes. Following the behavioral interaction, plasma cortisol and central monoamine concentrations were analyzed. Trout treated with CRF were victorious in approximately 60% of the aggressive encounters against aCSF treated opponents. Trout injected with CRF exhibited a reduction in the total number of attacks and decreased latency to attack. When trout were divided winners and losers, only victorious CRF-treated fish exhibited a reduced latency to attack and fewer retreats. Social stress increased cortisol levels in both winners and losers of aggressive interaction. This effect was enhanced with the additional stress incurred from icv injection of aCSF. However, icv CRF in addition to social stress decreased plasma cortisol in both winners and losers. While aggression stimulated significant changes in serotonergic and dopaminergic activity, the magnitude and direction were dependent on limbic brain region, CRF dose, and outcome of social aggression. With broad effects on aggressive behavior, anxiety, stress responsiveness, and central monoaminergic activity, CRF plays an important role modulating the behavioral components of social interaction.
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DOI：
10.1051/rnd:19820101
发表时间：
1982-01-01
期刊：
REPRODUCTION NUTRITION DEVELOPMENT
影响因子：
--
作者：
BILLARD, R;PETER, RE
通讯作者：
PETER, RE
影响因子：
2.9
作者：
DEPEDRO, N;ALONSOGOMEZ, AL;ALONSOBEDATE, M
通讯作者：
ALONSOBEDATE, M
影响因子：
3
作者：
De Pedro, N;Pinillos, ML;Delgado, MJ
通讯作者：
Delgado, MJ
影响因子：
2.7
作者：
Gammie, SC;Hasen, NS;D'Anna, KL
通讯作者：
D'Anna, KL
影响因子：
2.7
作者：
Emerson, AJ;Kappenman, DP;Summers, CH
通讯作者：
Summers, CH