Brain mediators of cardiovascular responses to social threat: part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity.
Brain mediators of cardiovascular responses to social threat: part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity.
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DOI：
10.1016/j.neuroimage.2009.05.043
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发表时间：
2009-09
期刊：
影响因子：
5.7
通讯作者：
Taylor, Stephan F.
中科院分区：
文献类型：
--
作者：
Wager, Tor D.;Waugh, Christian E.;Lindquist, Martin;Noll, Doug C.;Fredrickson, Barbara L.;Taylor, Stephan F.
社会威胁是精神“压力”的一个关键组成部分，也是身体消极情绪和生理反应的有力产生者。然而，人类大脑如何处理社会背景并驱动外周生理学，人们对此知之甚少。人类神经影像学和动物研究涉及背内侧前额叶皮层（MPFC），虽然这个异质性区域可能包含多个子区域，与生理反应和调节有不同的关系。我们使用功能磁共振成像结合一种新的多层次路径分析方法，以确定一个公共演讲准备任务（社会评价威胁，SET）对心率（HR）的影响的大脑介质。该模型提供了跨时间（人内）和跨个体（人与人之间）连接实验操纵的威胁，区域fMRI活动和生理输出的功能通路的测试。因此，它集成了时间序列的连接性和个体差异分析在同一路径模型。这些结果为MPFC的两个可分离的、反向偶联的子区域独立介导HR反应提供了证据。SET引起的活动增加，在背侧pregenual扣带区，其活动与HR增加。相反，SET导致右腹内侧/内侧眼眶区域的活动减少，伴随HR增加。每个途径中偶联强度的个体差异独立预测HR反应性的个体差异。这些结果强调了MPFC在产生对威胁的生理反应中的重要性和异质性。
Social threat is a key component of mental “stress” and a potent generator of negative emotions and physiological responses in the body. How the human brain processes social context and drives peripheral physiology, however, is relatively poorly understood. Human neuroimaging and animal studies implicate the dorsal medial prefrontal cortex (MPFC), though this heterogeneous region is likely to contain multiple sub-regions with diverse relationships with physiological reactivity and regulation. We used fMRI combined with a novel multi-level path analysis approach to identify brain mediators of the effects of a public speech preparation task (social evaluative threat, SET) on heart rate (HR). This model provides tests of functional pathways linking experimentally manipulated threat, regional fMRI activity, and physiological output, both across time (within person) and across individuals (between persons). It thus integrates time series connectivity and individual difference analyses in the same path model. The results provide evidence for two dissociable, inversely coupled sub-regions of MPFC that independently mediated HR responses. SET caused activity increases in a more dorsal pregenual cingulate region, whose activity was coupled with HR increases. Conversely, SET caused activity decreases in a right ventromedial/medial orbital region, which were coupled with HR increases. Individual differences in coupling strength in each pathway independently predicted individual differences in HR reactivity. These results underscore both the importance and heterogeneity of MPFC in generating physiological responses to threat.
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