The development of the ventral prefrontal cortex and social flexibility.

The development of the ventral prefrontal cortex and social flexibility.
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DOI:
10.1016/j.dcn.2011.01.002
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发表时间:
2011-07
影响因子:
4.7
通讯作者:
Guyer, Amanda E.
Guyer, Amanda E.
中科院分区:
医学1区
文献类型:
--
作者:
Nelson, Eric E.;Guyer, Amanda E.

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在过去的几年里,许多对人类和动物的研究都表明,眶额和腹外侧前额叶皮质在产生灵活行为方面起着重要作用。我们认为,来自这些大脑区域的输入有助于在社会环境中产生灵活行为的三个功能:评价,抑制和规则使用。最近的研究还表明,前额皮质经历了一个漫长的成熟过程,在青春期之后很长时间。在这里,我们回顾的证据表明,这些前额叶区域的长期发展并行缓慢出现的灵活的社会行为的能力。我们还推测,组织社会行为的敏感期可能嵌入在这个发展的时间范围内。最后,我们讨论了前额叶皮层在青少年情绪和焦虑症中的作用,特别是当眶额和腹外侧前额叶皮层参与社会环境时。
Over the last several years a number of studies in both humans and animals have suggested that the orbitofrontal and ventrolateral prefrontal cortices play an important role in generating flexible behavior. We suggest that input from these brain regions contribute to three functions involved in generating flexible behavior within social contexts: valuation, inhibition, and rule use. Recent studies have also demonstrated that the prefrontal cortex undergoes a prolonged course of maturation that extends well after puberty. Here, we review evidence that the prolonged development of these prefrontal regions parallels a slowly emerging ability for flexible social behavior. We also speculate on the possibility that sensitive periods for organizing social behavior may be embedded within this developmental time-fame. Finally, we discuss the role of prefrontal cortex in adolescent mood and anxiety disorders, particularly as orbitofrontal and ventrolateral prefrontal cortices are engaged in a social context.
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