A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α.
A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α.
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DOI：
10.1186/s40001-017-0266-9
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发表时间：
2017-07-12
影响因子：
4.2
通讯作者：
Zhou XZ
中科院分区：
文献类型：
--
作者：
Bian AL;Hu HY;Rong YD;Wang J;Wang JX;Zhou XZ
本研究旨在探讨社区老年人肌肉减少症与炎症因子IL-6、TNF-α的关系。本研究共纳入441位接受健康检查的长者。受试者年龄>60岁，其中男性235例，女性206例。根据EWGSOP和AWGS制定的少肌症诊断标准，将受试者分为少肌症组和非少肌症组。调查研究对象的生活习惯、疾病状况、生化指标、IL-6和TNF-α水平。肌肉减少症的患病率男性为17.02%，女性为18.9%。在>80岁的老年受试者中，男性受试者的患病率为25.3%，女性受试者的患病率为35.1%。肌肉减少症患者吸烟史长，规律运动史短（P < 0.01）。骨骼肌减少组与非骨骼肌减少组的握力、去脂体重、骨矿物质含量、血浆白蛋白、血清肌酐、体脂含量比较，差异有统计学意义（P < 0.05）。IL-6和TNF-α水平在两组间差异有统计学意义（P < 0.05）。BMI与TNF-α呈正相关，ALB与IL-6呈负相关，BMI、VFA与TNF-α呈正相关，SMM、HDL-C、Hb、HG与IL-6呈负相关（P <0. 05）。多元线性回归分析显示，血浆ALB和BMI是TNF-α的独立危险因素，VFA是IL-6的独立危险因素。肌肉减少症的发生与不良的运动习惯、疾病史和营养状况有关。肌肉减少症的出现伴随着炎症因子TNF-α和IL-6水平的升高。血浆白蛋白、BMI和VFA是TNF和IL-6的炎症因子预测因子。
This report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α. A total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-α of these subjects were investigated. The morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-α levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-α levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-α levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-α, while VFA was the independent risk factor of IL-6. The onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-α and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.
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DOI：
10.1007/s13539-010-0014-2
发表时间：
2010-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
von Haehling S;Morley JE;Anker SD
通讯作者：
Anker SD
影响因子：
2.2
作者：
Morley, John E.
通讯作者：
Morley, John E.
DOI：
10.1093/gerona/55.12.m709
发表时间：
2000-12-01
影响因子：
5.1
作者：
Taaffe, DR;Harris, TB;Seeman, TE
通讯作者：
Seeman, TE
DOI：
10.1046/j.1532-5415.2002.50504.x
发表时间：
2002-11-01
影响因子：
6.3
作者：
Visser, M;Pluijm, SMF;Deeg, DJH
通讯作者：
Deeg, DJH
DOI：
10.1093/gerona/57.5.m326
发表时间：
2002-05-01
影响因子：
5.1
作者：
Visser, M;Pahor, M;Harris, TB
通讯作者：
Harris, TB