A Protocol for Cortical Type Analysis of the Human Neocortex Applied on Histological Samples, the Atlas of Von Economo and Koskinas, and Magnetic Resonance Imaging.
A Protocol for Cortical Type Analysis of the Human Neocortex Applied on Histological Samples, the Atlas of Von Economo and Koskinas, and Magnetic Resonance Imaging.
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DOI：
10.3389/fnana.2020.576015
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发表时间：
2020
影响因子：
2.9
通讯作者：
Zikopoulos B
中科院分区：
文献类型：
--
作者：
García-Cabezas MÁ;Hacker JL;Zikopoulos B
使用神经解剖学和成像方法将人类大脑皮层分为数百个区域。或者，皮质区域可以根据其层状分化程度分为几种皮质类型。皮质类型分析基于尼氏染色切片中观察到的整个大脑皮层层状特征的逐渐和系统的变化，对于理解大脑皮层的进化、发育、连接、功能和病理学的基本方面具有深远的意义。在本协议文件中，我们解释了皮质类型分析的一般原理，并提供了具有本分析所研究的层状结构基本特征的表格。我们将皮质类型分析应用于 von Economo 和 Koskinas 的人类大脑皮层图谱的显微照片，并提供表格和地图，其中包含该图谱的区域及其相应的皮质类型。最后，我们将皮质类型图与广泛使用的参考磁共振成像扫描中的 T1w/T2w 比率相关联。本协议文件中显示的人类大脑皮层的分析、表格和地图可用于根据结构模型的原理预测区域之间的连接模式，并确定它们在皮质层次结构中的级别。皮质类型还可以预测神经退行性疾病中异常蛋白质扩散到皮质层的水平。总之，皮质类型分析为人类新皮质的连通性、突触可塑性以及对神经和精神疾病的选择性脆弱性的定向研究提供了理论和实践框架。
The human cerebral cortex is parcellated in hundreds of areas using neuroanatomy and imaging methods. Alternatively, cortical areas can be classified into few cortical types according to their degree of laminar differentiation. Cortical type analysis is based on the gradual and systematic variation of laminar features observed across the entire cerebral cortex in Nissl stained sections and has profound implications for understanding fundamental aspects of evolution, development, connections, function, and pathology of the cerebral cortex. In this protocol paper, we explain the general principles of cortical type analysis and provide tables with the fundamental features of laminar structure that are studied for this analysis. We apply cortical type analysis to the micrographs of the Atlas of the human cerebral cortex of von Economo and Koskinas and provide tables and maps with the areas of this Atlas and their corresponding cortical type. Finally, we correlate the cortical type maps with the T1w/T2w ratio from widely used reference magnetic resonance imaging scans. The analysis, tables and maps of the human cerebral cortex shown in this protocol paper can be used to predict patterns of connections between areas according to the principles of the Structural Model and determine their level in cortical hierarchies. Cortical types can also predict the spreading of abnormal proteins in neurodegenerative diseases to the level of cortical layers. In summary, cortical type analysis provides a theoretical and practical framework for directed studies of connectivity, synaptic plasticity, and selective vulnerability to neurologic and psychiatric diseases in the human neocortex.
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影响因子：
5.7
作者：
Barbas H;García-Cabezas MÁ
通讯作者：
García-Cabezas MÁ
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4.6
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2.5
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作者：
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通讯作者：
BRAAK, E