Molecular structure study on the polyelectrolyte properties of actin filaments.
Molecular structure study on the polyelectrolyte properties of actin filaments.
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DOI：
10.1039/d1ra09280d
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发表时间：
2022
期刊：
影响因子：
3.9
通讯作者：
Marucho M
中科院分区：
文献类型：
--
作者：
Manrique-Bedoya S;Marucho M
准确表征肌动蛋白丝的弹性性质可能会提供更深入的了解的基本机制，管理细胞内离子波包在神经元中传播。最近，在体外和细胞内条件下，肌动蛋白丝的非线性长圆柱模型和电解质溶液的近似电化学理论被用来表征这些特性。本文采用肌动蛋白丝的分子结构模型，研究粗糙度和有限尺寸对平均电势，离子密度分布，电流和电导率的影响。我们用数值方法解出了电化学理论，而没有进一步的近似。我们的研究结果带来了新的见解灯丝的不规则的表面电荷密度和周围介质之间的电化学相互作用。灯丝结构模型的不规则形状产生了口袋或热点，其中电流密度达到比整个灯丝表面的相邻区域中的电流密度更高或更低的幅度。它还揭示了一个定义明确的非对称双电层的形成，其厚度大于通常用于对称模型的厚度。非平凡的分子结构粗糙度和离子凝聚贡献的电导率和电流沿沿着单个肌动蛋白丝。
An accurate characterization of the polyelectrolyte properties of actin filaments might provide a deeper understanding of the fundamental mechanisms governing the intracellular ionic wave packet propagation in neurons. Infinitely long cylindrical models for actin filaments and approximate electrochemical theories for the electrolyte solutions were recently used to characterize these properties in in vitro and intracellular conditions. This article uses a molecular structure model for actin filaments to investigate the impact of roughness and finite size on the mean electrical potential, ionic density distributions, currents, and conductivities. We solved the electrochemical theories numerically without further approximations. Our findings bring new insights into the electrochemical interactions between a filament's irregular surface charge density and the surrounding medium. The irregular shape of the filament structure model generated pockets, or hot spots, where the current density reached higher or lower magnitudes than those in neighboring areas throughout the filament surface. It also revealed the formation of a well-defined asymmetric electrical double layer with a thickness larger than that commonly used for symmetric models. Non-trivial molecular structure roughness and ion condensation contributions to the electrical conductivity and currents along single actin filaments.
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影响因子：
41.2
作者：
Patolsky, F;Weizmann, Y;Willner, I
通讯作者：
Willner, I
影响因子：
3.4
作者：
LIN, EC;CANTIELLO, HF
通讯作者：
CANTIELLO, HF
DOI：
10.1016/j.simpa.2021.100072
发表时间：
2021-05-01
期刊：
SOFTWARE IMPACTS
影响因子：
--
作者：
Marucho, Marcelo
通讯作者：
Marucho, Marcelo
影响因子：
5.6
作者：
Frieden, B. Roy;Gatenby, Robert
通讯作者：
Gatenby, Robert
影响因子：
41.2
作者：
Galland, Remi;Leduc, Patrick;Thery, Manuel
通讯作者：
Thery, Manuel