Baclofen effects on alcohol seeking, self-administration and extinction of seeking responses in a within-session design in baboons.
Baclofen effects on alcohol seeking, self-administration and extinction of seeking responses in a within-session design in baboons.
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在狒狒的会话设计中，巴氯芬对酒精寻求、自我管理和寻求反应消退的影响。
DOI：
10.1111/j.1369-1600.2012.00448.x
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发表时间：
2014-01
影响因子：
3.4
通讯作者：
Weerts EM
中科院分区：
文献类型：
--
作者：
Duke AN;Kaminski BJ;Weerts EM
巴氯芬是一种GABAB受体激动剂，目前正在研究作为一种潜在的治疗方法，以防止酒精依赖者复发饮酒。在目前的研究中，两组狒狒在强化的链式计划（CSR）下接受训练，其中有3个链接组件，每个组件与不同的反应要求和线索相关。满足第2个环节中的要求启动第3个环节，其中酒精（n=4）或首选非酒精饮料（Tang，n=5）可用于自我给药;未能完成环节2中的响应要求结束了会话（无法获得酒精或Tang）。在链接2中寻求反应被用作被认为参与复发的动机过程的指数。巴氯芬（0.1 - 2.4 mg/kg）的影响进行了检查，在酒精或唐访问和消光条件下。在CSR下，巴氯芬（1.8和2.4 mg/kg）显著降低（p<0.05）酒精自我给药反应和总g/kg酒精摄入量。相反，只有最高剂量的巴氯芬（2.4 mg/kg）减少了Tang的自我给药和消耗。在会话内消退条件下，巴氯芬（1.8和2.4毫克/公斤）促进消退响应酒精和唐，特别是在前10分钟的灭绝。巴氯芬可能有效地减少渴望和饮酒，虽然巴氯芬促进消除和抑制酒精和Tang自我管理表明这些作用可能与更普遍的抑制消费和条件行为有关。
Baclofen, a GABAB receptor agonist, is currently under investigation as a potential treatment to prevent relapse to drinking in alcohol dependent persons. In the current study, two groups of baboons were trained under a chained schedule of reinforcement (CSR), with 3 linked components, which were each correlated with different response requirements and cues. Fulfilling the requirement in the 2nd link initiated the 3rd link where either alcohol (n=4) or a preferred non-alcoholic beverage (Tang, n=5) was available for self-administration; failure to complete the response requirement in Link 2 ended the session (no access to alcohol or Tang). Seeking responses in Link 2 were used as indices of the motivational processes thought to be involved in relapse. The effects of baclofen (0.1 – 2.4 mg/kg) were examined under conditions with alcohol or Tang access and under extinction. Under the CSR baclofen (1.8 and 2.4 mg/kg) significantly decreased (p<0.05) alcohol self-administration responses and total g/kg alcohol intake. In contrast, only the highest dose of baclofen (2.4 mg/kg) reduced Tang self-administration and consumption. Under within-session extinction conditions, baclofen (1.8 and 2.4 mg/kg) facilitated extinction of responding for both alcohol and Tang, particularly during the first 10 min of extinction. Baclofen may be effective in reducing craving and alcohol drinking, although the facilitation of extinction and suppression of both alcohol and Tang self-administration by baclofen suggests these effects may be related to a more general suppression of consummatory and conditioned behaviors.
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DOI：
10.1111/j.1530-0277.2008.00662.x
发表时间：
2008-06-01
影响因子：
3.2
作者：
Kaminski, Barbara J.;Goodwin, Amy K.;Weerts, Elise M.
通讯作者：
Weerts, Elise M.
DOI：
10.1111/j.1530-0277.2008.00805.x
发表时间：
2009-01-01
影响因子：
3.2
作者：
Evans, Suzette M.;Bisaga, Adam
通讯作者：
Bisaga, Adam
影响因子：
2.8
作者：
Colombo, G;Serra, S;Gessa, GL
通讯作者：
Gessa, GL
影响因子：
2.3
作者：
DAOUST, M;SALIGAUT, C;BOISMARE, F
通讯作者：
BOISMARE, F
影响因子：
2.7
作者：
BULLOCK, DH
通讯作者：
BULLOCK, DH