Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors.
Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors.
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DOI：
10.1016/j.neuron.2019.12.006
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发表时间：
2020-03-04
期刊：
影响因子：
16.2
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Stephenson-Jones M;Bravo-Rivera C;Ahrens S;Furlan A;Xiao X;Fernandes-Henriques C;Li B
腹侧苍白球（VP）对于激励奖励寻求至关重要，也参与了惩罚避免，但它如何有助于这种相反的行为行动仍不清楚。在这里，我们表明，GABA能和神经递质能VP神经元选择性地控制行为，在相反的动机背景。在小鼠体内记录结合光遗传学揭示，这两个群体相反地编码积极和消极的动机价值，由动物的内部状态差异调制，并决定在动机冲突期间的行为反应。此外，GABA能VP神经元是必不可少的运动走向奖励在积极的动机背景下，但抑制运动在厌恶的背景下。相比之下，海马体能VP神经元对于避免威胁的运动是必不可少的，但在食欲背景下抑制运动。我们的研究结果表明，GABA能和神经元编码的VP驱动器的方法和避免，分别与它们的活动之间的平衡确定的类型的动机行为。Stephenson-Jones和Bravo-Rivera等人的研究表明，GABA能和多巴胺能腹侧苍白球神经元分别通过编码接近奖励和避免惩罚的驱动力来控制相反动机背景下的行为，它们的活动之间的平衡决定了接近或避免。
The ventral pallidum (VP) is critical for invigorating reward seeking and is also involved in punishment avoidance, but how it contributes to such opposing behavioural actions remains unclear. Here we show that GABAergic and glutamatergic VP neurons selectively control behaviour in opposing motivational contexts. In vivo recording combined with optogenetics in mice revealed that these two populations oppositely encode positive and negative motivational value, are differentially modulated by animal’s internal state and determine the behavioural response during motivational conflict. Furthermore, GABAergic VP neurons are essential for movements towards reward in a positive motivational context, but suppress movements in an aversive context. In contrast, glutamatergic VP neurons are essential for movements to avoid a threat but suppress movements in an appetitive context. Our results indicate that GABAergic and glutamatergic VP neurons encode the drive for approach and avoidance, respectively, with the balance between their activities determining the type of motivational behaviour. Stephenson-Jones and Bravo-Rivera et al. show that GABAergic and glutamatergic ventral pallidal neurons control behavior in opposing motivational contexts, by encoding the drive for approaching reward and avoiding punishment, respectively, with the balance between their activities determining approach or avoidance.
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