Structure of spike count correlations reveals functional interactions between neurons in dorsolateral prefrontal cortex area 8a of behaving primates.
Structure of spike count correlations reveals functional interactions between neurons in dorsolateral prefrontal cortex area 8a of behaving primates.
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DOI：
10.1371/journal.pone.0061503
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Martinez-Trujillo JC
中科院分区：
文献类型：
--
作者：
Leavitt ML;Pieper F;Sachs A;Joober R;Martinez-Trujillo JC
灵长类动物背外侧前额叶皮质(DlPFC)内的神经元根据其视觉空间调节而聚集在微柱中。一个仍然很少被研究的问题是，这种解剖排列如何影响行为过程中神经元之间的功能相互作用。为了研究这个问题，我们在两只猕猴的dlPFC区8a植入了4 mm×4 mm的多电极阵列，并测量了动物保持静止凝视时同时记录到的神经元反应之间的棘波计数相关性(RSC)。在较大的神经元间距范围内(从0.4 mm到4 mm)，RSC的正值和负值均显著高于偶然预测。≤角距离为90°的感受野神经元之间的阳性RSC较强，并随神经元间物理距离的增加而递减。RFS间隔90°的神经元之间的负RSC更强，且随神经元间距离的增加而增加。我们的结果表明，dlPFC神经元之间的短期和远程功能相互作用取决于它们之间的物理距离和它们的视觉空间调谐偏好之间的关系。具有相似视觉空间调谐的神经元显示正RSC，随着神经元之间的距离而衰减，提示相邻微柱内和相邻微柱之间的兴奋性相互作用。来自空间分离微柱的不同调谐的神经元显示负的RSC，其随着神经元之间的距离而增加，暗示着抑制相互作用。这一结果模式表明，前额神经元之间的功能相互作用与解剖学研究中报道的连接模式密切相关。这种相互作用可能对前额叶皮质在竞争分心物体存在时将注意力分配到目标上的作用很重要。
Neurons within the primate dorsolateral prefrontal cortex (dlPFC) are clustered in microcolumns according to their visuospatial tuning. One issue that remains poorly investigated is how this anatomical arrangement influences functional interactions between neurons during behavior. To investigate this question we implanted 4 mm×4 mm multielectrode arrays in two macaques' dlPFC area 8a and measured spike count correlations (rsc) between responses of simultaneously recorded neurons when animals maintained stationary gaze. Positive and negative rsc were significantly higher than predicted by chance across a wide range of inter-neuron distances (from 0.4 to 4 mm). Positive rsc were stronger between neurons with receptive fields (RFs) separated by ≤90° of angular distance and progressively decreased as a function of inter-neuron physical distance. Negative rsc were stronger between neurons with RFs separated by >90° and increased as a function of inter-neuron distance. Our results show that short- and long-range functional interactions between dlPFC neurons depend on the physical distance between them and the relationship between their visuospatial tuning preferences. Neurons with similar visuospatial tuning show positive rsc that decay with inter-neuron distance, suggestive of excitatory interactions within and between adjacent microcolumns. Neurons with dissimilar tuning from spatially segregated microcolumns show negative rsc that increase with inter-neuron distance, suggestive of inhibitory interactions. This pattern of results shows that functional interactions between prefrontal neurons closely follow the pattern of connectivity reported in anatomical studies. Such interactions may be important for the role of the prefrontal cortex in the allocation of attention to targets in the presence of competing distracters.
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影响因子：
64.8
作者：
Gutnisky, Diego A.;Dragoi, Valentin
通讯作者：
Dragoi, Valentin
影响因子：
25
作者：
Constantinidis, C;Williams, GV;Goldman-Rakic, PS
通讯作者：
Goldman-Rakic, PS
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作者：
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Sawaguchi, Toshiyuki
影响因子：
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作者：
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通讯作者：
GOLDMANRAKIC, PS
影响因子：
2.5
作者：
BUGBEE, NM;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS