Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder.
Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder.
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DOI：
10.1002/gps.4829
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发表时间：
2018-03
影响因子：
4
通讯作者：
Mulsant BH
中科院分区：
文献类型：
--
作者：
Vaccarino SR;Rajji TK;Gildengers AG;Waters SES;Butters MA;Menon M;Blumberger DM;Voineskos AN;Miranda D;Mulsant BH
患有双相情感障碍（BD）的老年患者存在不同程度的认知障碍。随着时间的推移，压力、情绪发作和合并症会增加身体的非稳态负荷。我们评估了非稳态负荷与更传统的医疗负担指标在多大程度上解释了这一人群认知的异质性。对35例老年BD患者和30例年龄、性别和教育程度相当的对照组患者进行了一项综合评估，包括神经心理电池和9项生理指标，以确定非稳态负荷。非稳态负荷，医疗负担和认知之间的关系进行了评估。与心理健康的对照组相比，患者在四个认知领域（信息处理速度/执行功能、延迟记忆、语言和视觉能力）整体受损;并表现出更大的医疗负担，但无不同的非稳态负荷。在相关分析和多元回归分析中，非稳态负荷，而不是医疗负担，与延迟记忆表现相关。情感正常的老年BD患者在多个认知领域受损，医疗负担高。他们的记忆表现与非稳态负荷的关系比与传统的医疗负担措施的关系更密切。这些发现需要被复制和纵向扩展。
Older patients with Bipolar Disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes and comorbidities increase the body’s allostatic load. We assessed the extent to which allostatic load vs. more traditional measures of medical burden account for the heterogeneity in cognition in this population. 35 older euthymic patients with BD and 30 age-, gender-, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load. The relationship among allostatic load, medical burden, and cognition was assessed. Compared with the mentally healthy comparators, patients were impaired globally, and in four cognitive domains -- information-processing speed / executive functioning, delayed memory, language, and visuomotor ability; and presented with greater medical burden but not a different allostatic load. Allostatic load, but not medical burden, was associated with delayed memory performance both in a correlational analysis and in a multivariate regression analysis. Euthymic older patients with BD are impaired on several cognitive domains and have high medical burden. Their memory performance is more strongly associated with allostatic load than with traditional measures of medical burden. These findings need to be replicated and extended longitudinally.
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影响因子：
7.2
作者：
Gildengers, Ariel G.;Butters, Meryl A.;Mulsant, Benoit H.
通讯作者：
Mulsant, Benoit H.
影响因子：
7.2
作者：
Gildengers, Ariel G.;Whyte, Ellen M.;Mulsant, Benoit H.
通讯作者：
Mulsant, Benoit H.
影响因子：
5.4
作者：
Martínez-Arán, A;Vieta, E;Salamero, M
通讯作者：
Salamero, M
DOI：
10.1097/chi.0b013e318196b907
发表时间：
2009-03
影响因子：
13.3
作者：
Pavuluri MN;West A;Hill SK;Jindal K;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
5.4
作者：
Gildengers AG;Butters MA;Chisholm D;Anderson SJ;Begley A;Holm M;Rogers JC;Reynolds CF 3rd;Mulsant BH
通讯作者：
Mulsant BH