Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences.
Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences.
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DOI：
10.1016/j.nicl.2018.02.006
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kremen WS
中科院分区：
文献类型：
--
作者：
McEvoy LK;Fennema-Notestine C;Elman JA;Eyler LT;Franz CE;Hagler DJ Jr;Hatton SN;Lyons MJ;Panizzon MS;Dale AM;Kremen WS
大量饮酒与大脑的有害变化有关，但适度饮酒的关联尚不清楚。我们检查了 377 名参加越南时代双胞胎衰老研究 (VETSA) 的中年男性（56-66 岁；平均 61.8±2.6 岁）的饮酒与大脑白质健康之间的关系。获得 T1、T2、质子密度和扩散加权磁共振图像。对 12 个主要白质束的扩散测量进行了量化。还对整体白质病变（WML）负担进行了量化。混合效应线性模型检查了酒精摄入量的扩散率和 WML 的差异。针对众多人口、健康和生活方式变量进行了分析调整。研究发现，酒精摄入量与多个束的分数各向异性 (FA) 之间存在倒 U 型关联，包括额枕下束、钩束、上纵束、小镊子和丘脑前放射束。在这些区域中，FA 随着酒精摄入量的增加而增加，在适度饮酒（14 天内喝 9-28 杯）时达到峰值，并随着大量饮酒而下降。排除糖尿病或高血压患者后，相关性仍然显着。 WML 负担呈 U 形关联，从不饮酒者和重度饮酒者（14 天内饮酒超过 28 杯）的负担最高。在排除高血压患者后，这种关联不再显着，因为重度饮酒者的 WML 负担与其他饮酒者不再有差异。这表明与大量饮酒相关的高血压可能会导致重度饮酒者中观察到的 WML 负担。总之，这些相关结果表明，在中年男性中，适量饮酒可能与更好的白质健康指标相关，特别是微观结构指标，而超过推荐指南的饮酒可能与微观结构和宏观结构白质损伤相关。在中年男性中，大脑白质指标因酒精摄入量而异。适度饮酒者的各向异性分数（FA）最高。 FA随着饮酒量的增加而降低（平均>2次/天）。从不饮酒者和大量饮酒者的白质病变负担最高。轻度至中度饮酒与白质健康指数改善相关。
Heavy alcohol consumption is associated with deleterious changes in the brain but associations of moderate alcohol intake are not well understood. We examined the association of alcohol consumption with brain white matter health in 377 middle-aged men (56–66 years old; mean 61.8 ± 2.6 years) who were participants in the Vietnam Era Twin Study of Aging (VETSA). T1-, T2-, proton density-, and diffusion-weighted magnetic resonance images were obtained. Diffusion measures were quantified from 12 major white matter tracts. Global white matter lesion (WML) burden was also quantified. Mixed effects linear models examined differences in diffusivity and WMLs by amount of alcohol intake. Analyses adjusted for numerous demographic, health, and lifestyle variables. An inverted-U association was found between alcohol intake and fractional anisotropy (FA) in several tracts, including the inferior-frontal-occipital fasciculus, uncinate fasciculus, superior longitudinal fasciculus, the forceps minor and the anterior thalamic radiations. In these tracts, FA increased with increasing alcohol intake, peaking with moderate alcohol intake (9–28 drinks in 14 days), and declining with heavier intake. Associations remained significant after exclusion of individuals with diabetes or hypertension. There was a U-shaped association in WML burden with highest burden among never drinkers and heavy drinkers (>28 drinks in 14 days). This association was no longer significant after exclusion of individuals with hypertension, since WML burden among heavy drinkers no longer differed from that of other drinkers. This suggests that hypertension related to heavy alcohol intake may contribute to WML burden observed among heavy drinkers. Together, these correlational results suggest that among middle-aged men, moderate drinking may be associated with metrics of better white matter health, particularly microstructural measures, whereas drinking beyond recommended guidelines may be associated with both microstructural and macrostructural white matter damage. In middle-aged men brain white matter metrics differed by amount of alcohol intake. Fractional anisotropy (FA) was highest among moderate drinkers. FA decreased with heavier drinking (>2 drinks/day, on average). Never drinkers and heavy drinkers had highest white matter lesion burden. Light to moderate drinking is associated with indices of better white matter health.
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影响因子：
5.7
作者：
Klawiter, Eric C.;Schmidt, Robert E.;Trinkaus, Kathryn;Liang, Hsiao-Fang;Budde, Matthew D.;Naismith, Robert T.;Song, Sheng-Kwei;Cross, Anne H.;Benzinger, Tammie L.
通讯作者：
Benzinger, Tammie L.
影响因子：
8.3
作者：
de Groot, Marius;Verhaaren, Benjamin F. J.;Vernooij, Meike W.
通讯作者：
Vernooij, Meike W.
影响因子：
0.9
作者：
Kremen, William S.;Franz, Carol E.;Lyons, Michael J.
通讯作者：
Lyons, Michael J.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
7.1
作者：
den Heijer, T;Vermeer, SE;Breteler, MMB
通讯作者：
Breteler, MMB