Occupational Exposure to Carbon Nanotubes and Carbon Nanofibres: More Than a Cobweb.
Occupational Exposure to Carbon Nanotubes and Carbon Nanofibres: More Than a Cobweb.
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DOI：
10.3390/nano11030745
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发表时间：
2021-03-16
期刊：
影响因子：
--
通讯作者：
Guseva Canu I
中科院分区：
文献类型：
--
作者：
Bergamaschi E;Garzaro G;Wilson Jones G;Buglisi M;Caniglia M;Godono A;Bosio D;Fenoglio I;Guseva Canu I
碳纳米管(CNT)和碳纳米纤维(CNF)被错误地认为是单一材料实体。相反，它们应该被视为一类异质材料，具有不同的性质，在体外和体内都能产生特定的生物学结果。鉴于碳纳米管/碳纳米管工业生产的增长速度，获得关于它们的生物活性及其对人类的危险影响的全面知识变得至关重要。通过吸入进行的动物研究表明，某些碳纳米管/碳纳米管可引起炎症和肺组织重塑等有害影响。它们的物理化学性质、生物行为和生物持久性使其类似于石棉纤维。人体研究表明，接触碳纳米管/碳纳米管的工人有一些轻微的影响。然而，由于他们的横截面设计，研究人员至今还无法确切地证明这种暴露与所观察到的影响之间的因果关系。对可接受暴露水平的估计应保证进行适当的风险管理。本次审查的目的是挑战将CNTS/CNFS作为一个单一、统一的物质实体的概念，并推动建立能够适当提供风险评估和管理框架的标准化危险和暴露评估方法。
Carbon nanotubes (CNTs) and carbon nanofibers (CNFs) are erroneously considered as singular material entities. Instead, they should be regarded as a heterogeneous class of materials bearing different properties eliciting particular biological outcomes both in vitro and in vivo. Given the pace at which the industrial production of CNTs/CNFs is increasing, it is becoming of utmost importance to acquire comprehensive knowledge regarding their biological activity and their hazardous effects in humans. Animal studies carried out by inhalation showed that some CNTs/CNFs species can cause deleterious effects such as inflammation and lung tissue remodeling. Their physico-chemical properties, biological behavior and biopersistence make them similar to asbestos fibers. Human studies suggest some mild effects in workers handling CNTs/CNFs. However, owing to their cross-sectional design, researchers have been as yet unable to firmly demonstrate a causal relationship between such an exposure and the observed effects. Estimation of acceptable exposure levels should warrant a proper risk management. The aim of this review is to challenge the conception of CNTs/CNFs as a single, unified material entity and prompt the establishment of standardized hazard and exposure assessment methodologies able to properly feed risk assessment and management frameworks.
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影响因子：
3.8
作者：
Fatkhutdinova LM;Khaliullin TO;Vasil'yeva OL;Zalyalov RR;Mustafin IG;Kisin ER;Birch ME;Yanamala N;Shvedova AA
通讯作者：
Shvedova AA
影响因子：
10
作者：
Fraser K;Kodali V;Yanamala N;Birch ME;Cena L;Casuccio G;Bunker K;Lersch TL;Evans DE;Stefaniak A;Hammer MA;Kashon ML;Boots T;Eye T;Hubczak J;Friend SA;Dahm M;Schubauer-Berigan MK;Siegrist K;Lowry D;Bauer AK;Sargent LM;Erdely A
通讯作者：
Erdely A
DOI：
10.1080/15287394.2013.834855
发表时间：
2013-09-17
影响因子：
2.6
作者：
Aldieri, E.;Fenoglio, I.;Fubini, B.
通讯作者：
Fubini, B.
影响因子：
2.6
作者：
Dahm, Matthew M.;Bertke, Stephen;Schubauer-Berigan, Mary K.
通讯作者：
Schubauer-Berigan, Mary K.
DOI：
10.1016/j.ijheh.2020.113472
发表时间：
2020-04-01
影响因子：
6
作者：
Canu, I. Guseva;Batsungnoen, K.;Hopf, N. B.
通讯作者：
Hopf, N. B.