Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China.
Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China.
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DOI：
10.1186/s12879-015-0863-6
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发表时间：
2015-03-13
影响因子：
3.7
通讯作者：
Ba-Thein W
中科院分区：
文献类型：
--
作者：
Cui B;Zhang D;Pan H;Zhang F;Farrar J;Law F;van Doorn HR;Wu B;Ba-Thein W
急性呼吸道感染(ARI)在儿童中很常见，主要由病毒引起，但在ARIS中检测多种病毒的意义尚不清楚。本文对汕头市中国南部地区儿童呼吸道感染的14种呼吸道病毒及其相关气象因素进行了调查。从2010年12月至2011年11月到三级医院门诊就诊的1,074例ARIS儿童鼻咽拭子中收集了14种呼吸道病毒-流感病毒(流感病毒)、呼吸道合胞病毒(RSV A和B)、人类冠状病毒(hCoV：229E、OC43、HKU1、NL63)、人类偏肺病毒(hMPV A和B)、副流感病毒(PIV1-4)、人类鼻病毒(HRV A、B、C)、肠道病毒(EV)、腺病毒(ADV)、人类博卡病毒(HBoV)和人类细小病毒(HPeV)。我们在82.3%(884/1,074)的患者中发现了至少一种病毒，在38.6%(415/1,074)的患者中发现了多种病毒。EV和HRV是最常见的单项病毒(42.3%，374/884和39.9%，353/884)和联合检测对(23.1%，96/415)。在过去一年中，记录到了重叠的病毒季节性趋势，EV呈双峰，其他病毒呈单峰。Logistic回归分析显示，EV与平均温湿度、hCoV、PIV4呈正相关，与HRV、PIV3、hBoV呈负相关。HRV与EV、PIV3呈负相关。这项研究报告了在儿童ARI病例中高的病毒检测和联合检测率，主要是由于EV和HRV。许多病毒全年流行，与温度、湿度和风速有相似的季节性趋势。在统计上，这些病毒之间存在显著的关联。了解多病毒的病原学和病毒之间的相互作用值得进一步研究。本文的在线版本(doi：10.1186/s12879-0150863-6)包含补充材料，授权用户可以使用。
Acute respiratory infections (ARIs) are common in children and mostly caused by viruses, but the significance of the detection of multiple viruses in ARIs is unclear. This study investigated 14 respiratory viruses in ARIs among children and associated meteorological factors in Shantou, southern China. Paired nasal/throat-flocked swabs collected from 1,074 children with ARIs, who visited outpatient walk-in clinics in a tertiary hospital between December 2010 and November 2011, were examined for fourteen respiratory viruses - influenza viruses (FluA, FluB), respiratory syncytial viruses (RSV A and B), human coronaviruses (hCoV: 229E, OC43, HKU1, NL63), human metapneumoviruses (hMPV A and B), parainfluenza viruses (PIV1-4), human rhinoviruses (HRV A, B, C), enteroviruses (EV), adenoviruses (ADV), human bocavirus (hBoV), and human parechoviruses (hPeV) - by multiplex real-time PCR. We identified at least one virus in 82.3% (884/1,074) and multiple viruses in 38.6% (415/1,074) of patients. EV and HRV were the most frequently detected single viruses (42.3%, 374/884 and 39.9%, 353/884 respectively) and co-detected pair (23.1%, 96/415). Overlapping seasonal trends of viruses were recorded over the year, with dual peaks for EV and single peaks for the others. By logistic regression analysis, EV was positively associated with the average temperature and humidity, hCoV, and PIV4, but negatively with HRV, PIV3, and hBoV. HRV was inversely associated with EV and PIV3. This study reports high viral detection and co-detection rates in pediatric ARI cases mainly due to EV and HRV. Many viruses circulated throughout the year with similar seasonal trends in association with temperature, humidity, and wind velocity. Statistically significant associations were present among the viruses. Understanding the polyviral etiology and viral interactions in the cases with multiple viruses warrants further studies. The online version of this article (doi:10.1186/s12879-015-0863-6) contains supplementary material, which is available to authorized users.
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