Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years.
Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years.
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DOI：
10.1186/1471-2431-12-32
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发表时间：
2012-03-20
期刊：
影响因子：
2.4
通讯作者：
Chan YF
中科院分区：
文献类型：
--
作者：
Khor CS;Sam IC;Hooi PS;Quek KF;Chan YF
病毒性呼吸道感染（RTI）在东南亚热带国家研究相对不足。在温带国家，已报告呼吸道病毒的季节性活动，特别是与温度相关，而在热带国家，呼吸道病毒活动与湿度和降雨的相关性不一致。从1982年至2008年进行了一项回顾性研究，以调查在马来西亚吉隆坡三级医院因RTI住院的儿童（≤ 5岁）的病毒病原学。该研究共纳入了1982-2008年期间在医院诊断病毒学实验室收到的所有≤ 5岁儿童的10269份呼吸道样本。进行免疫荧光染色（针对呼吸道合胞病毒（RSV）、甲型和B型流感病毒、1-3型副流感病毒和腺病毒）和病毒分离。确定了每年的住院率和实验室确认的病毒性RTI的年度模式。采用单因素方差分析对病例的人口学参数进行分析。采用多元回归和斯皮尔曼等级相关分析RSV病例与气象参数的相关性。共有2708例病例通过免疫荧光检测和病毒培养得到实验室确认，最常检测到的是RSV（1913例，70.6%）、副流感病毒（357例，13.2%）、流感病毒（297例，11.0%）和腺病毒（141例，5.2%）。感染RSV的儿童年龄明显较小，感染流感病毒的儿童年龄明显较大。四种主要病毒全年都会引起疾病，RSV在9月至12月出现季节性高峰。RSV月发病率与降雨天数呈正相关，与相对湿度和温度呈负相关。在马来西亚吉隆坡住院儿童的呼吸道样本中，通常检测到病毒性呼吸道感染，特别是由RSV引起的。与温带国家一样，马来西亚热带地区的RSV感染也引起季节性年度流行病，这对预防和疫苗接种计划有影响。
Viral respiratory tract infections (RTI) are relatively understudied in Southeast Asian tropical countries. In temperate countries, seasonal activity of respiratory viruses has been reported, particularly in association with temperature, while inconsistent correlation of respiratory viral activity with humidity and rain is found in tropical countries. A retrospective study was performed from 1982-2008 to investigate the viral etiology of children (≤ 5 years old) admitted with RTI in a tertiary hospital in Kuala Lumpur, Malaysia. A total of 10269 respiratory samples from all children ≤ 5 years old received at the hospital's diagnostic virology laboratory between 1982-2008 were included in the study. Immunofluorescence staining (for respiratory syncytial virus (RSV), influenza A and B, parainfluenza types 1-3, and adenovirus) and virus isolation were performed. The yearly hospitalization rates and annual patterns of laboratory-confirmed viral RTIs were determined. Univariate ANOVA was used to analyse the demographic parameters of cases. Multiple regression and Spearman's rank correlation were used to analyse the correlation between RSV cases and meteorological parameters. A total of 2708 cases were laboratory-confirmed using immunofluorescence assays and viral cultures, with the most commonly detected being RSV (1913, 70.6%), parainfluenza viruses (357, 13.2%), influenza viruses (297, 11.0%), and adenovirus (141, 5.2%). Children infected with RSV were significantly younger, and children infected with influenza viruses were significantly older. The four main viruses caused disease throughout the year, with a seasonal peak observed for RSV in September-December. Monthly RSV cases were directly correlated with rain days, and inversely correlated with relative humidity and temperature. Viral RTIs, particularly due to RSV, are commonly detected in respiratory samples from hospitalized children in Kuala Lumpur, Malaysia. As in temperate countries, RSV infection in tropical Malaysia also caused seasonal yearly epidemics, and this has implications for prophylaxis and vaccination programmes.
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影响因子：
11.8
作者：
du Prel, Jean-Baptist;Puppe, Wolfram;Schmitt, Heinz-Josef
通讯作者：
Schmitt, Heinz-Josef
影响因子：
3.3
作者：
Thomazelli, Luciano M.;Vieira, Sandra;Durigon, Edison L.
通讯作者：
Durigon, Edison L.
影响因子：
28.2
作者：
Samransamruajkit, R;Thanasugarn, W;Poovorawan, Y
通讯作者：
Poovorawan, Y
影响因子：
9.4
作者：
Sung, Rita Y. T.;Chan, Paul K. S.;Nelson, E. Anthony S.
通讯作者：
Nelson, E. Anthony S.
DOI：
10.1016/j.jinf.2009.05.009
发表时间：
2009-08
期刊：
The Journal of infection
影响因子：
--
作者：
Linsuwanon P;Payungporn S;Samransamruajkit R;Posuwan N;Makkoch J;Theanboonlers A;Poovorawan Y
通讯作者：
Poovorawan Y