Phylogeny and ontogeny of the renin-angiotensin system: Current view and perspectives.

Phylogeny and ontogeny of the renin-angiotensin system: Current view and perspectives.
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DOI:
10.1016/j.cbpa.2020.110879
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发表时间:
2021-04
期刊:
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子:
--
通讯作者:
Sequeira-Lopez MLS
Sequeira-Lopez MLS
中科院分区:
其他
文献类型:
--
作者:
Nishimura H;Sequeira-Lopez MLS

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肾素-血管紧张素系统(RAS)在脊椎动物中进化较早,并在整个脊椎动物系统发育过程中保持功能,并适应了各种环境。RAS在调节血压、体液电解质平衡和组织稳态中起着至关重要的作用。RAS也在肾脏和肾外组织的早期个体发育中表达,并发挥独特的血管生长和分化功能。在这篇简短的综述中,我们描述了分子遗传学和全动物方法的进展,并讨论了RAS在胚胎发育和脊椎动物系统发育中的相似之处和独特之处。
The renin-angiotensin system (RAS) evolved early amongst vertebrates and remains functioning throughout the vertebrate phylogeny and has adapted to various environments. The RAS is crucial for the regulation of blood pressure, fluid-electrolyte balance and tissue homeostasis. The RAS is also expressed during early ontogeny in renal and extra-renal tissues, and exerts unique vascular growth and differentiation functions. In this brief review, we describe advances from molecular-genetic and whole animal approaches and discuss similarities and unique aspects of the RAS in the context of embryonic development and vertebrates’ phylogeny.
DOI: 10.1152/ajpheart.1979.237.2.h105
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