Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China.
Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China.
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中国职业工人中全氟烷基酸（PFAA）的出现情况、时间趋势和半衰期
DOI：
10.1038/srep38039
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发表时间：
2016-12-01
影响因子：
4.6
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Fu J;Gao Y;Cui L;Wang T;Liang Y;Qu G;Yuan B;Wang Y;Zhang A;Jiang G
收集2008年至2012年某氟化工厂工人的配对血清和尿液样本（n = 302），调查氟化工厂工人全氟辛酸的水平、时间趋势和半衰期。在血清中检测到高水平的全氟己烷磺酸盐（PFHxS）、全氟辛酸（PFOA）和全氟辛烷磺酸盐（PFOS），中位浓度分别为764、427和1725 ng mL−1。采用一级动力学模型，以血清中全氟辛酸的日清除率和年下降率估算全氟辛酸在工人体内的半衰期。按日清除率计算，PFHxS、PFOA和PFOS的几何平均值和中位值分别为14.7和11.7年、4.1和4.0年、32.6和21.6年，按年下降率计算，它们分别为3.6、1.7和1.9年。通过有限的清除途径信息估计的半衰期可被视为PFAAs的上限，然而，两种估计方法之间的巨大差异表明PFAAs在人体中存在除肾脏清除外的其他重要消除途径。本研究中通过年下降率估计的半衰期是有史以来报告的最短值，由于持续接触全氟辛酸的水平很高，固有半衰期可能更短。
Paired serum and urine samples were collected from workers in a fluorochemical plant from 2008 to 2012 (n = 302) to investigate the level, temporal trends, and half-lives of PFAAs in workers of a fluorochemical plant. High levels of perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), and perfluorooctanesulfonate (PFOS) were detected in serum with median concentrations of 764, 427, and 1725 ng mL−1, respectively. The half-lives of PFAAs in workers were estimated by daily clearance rates and annual decline rates of PFAAs in serum by a first-order model. The geometric mean and median value for PFHxS, PFOA, and PFOS were 14.7 and 11.7, 4.1 and 4.0, 32.6 and 21.6 years, respectively, by the daily clearance rates, and they were 3.6, 1.7, and 1.9 years estimated by annual decline rates. The half-lives estimated by the limited clearance route information could be considered as the upper limits for PFAAs, however, the huge difference between two estimated approaches indicated that there were other important elimination pathways of PFAAs other than renal clearance in human. The half-lives estimated by annual decline rates in the present study were the shortest values ever reported, and the intrinsic half-lives might even shorter due to the high levels of ongoing exposure to PFAAs.
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影响因子：
1.2
作者：
Pan Yuan-Yuan;Shi Ya-Li;Cai Ya-Qi
通讯作者：
Cai Ya-Qi
影响因子：
4.3
作者：
Harada, Kouji H.;Hashida, Shuhei;Koizumi, Akio
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Koizumi, Akio
影响因子：
6.1
作者：
Lupton, Sara J.;Huwe, Janice K.;Johnston, John J.
通讯作者：
Johnston, John J.
影响因子：
11.4
作者：
Lopez-Espinosa, Maria-Jose;Fletcher, Tony;Leonardi, Giovanni
通讯作者：
Leonardi, Giovanni
职业暴露工人家庭成员的全氟烷基酸水平升高：粉尘转移的重要性
影响因子：
4.6
作者：
Fu J;Gao Y;Wang T;Liang Y;Zhang A;Wang Y;Jiang G
通讯作者：
Jiang G