Emerging infections and pregnancy.

Emerging infections and pregnancy.
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新出现的感染和怀孕。

DOI:
10.3201/eid1211.060152
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发表时间:
2006-11
影响因子:
11.8
通讯作者:
Rasmussen SA
Rasmussen SA
中科院分区:
医学2区
文献类型:
--
作者:
Jamieson DJ;Theiler RN;Rasmussen SA

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妊娠期免疫变化可能增加对某些细胞内病原体的易感性。应对新发感染的一个关键组成部分是考虑到特殊人群,包括孕妇。成功怀孕取决于妇女的免疫系统是否能适应基因上的异种胎儿。虽然免疫系统的变化还没有被很好地理解,但从细胞介导的免疫向体液免疫的转变被认为是发生的。这些免疫变化可能改变孕妇对传染病的易感性和严重程度。例如,怀孕可能增加对弓形虫病和李斯特菌病的易感性,可能增加疾病的严重程度,并增加流感和水痘的死亡率。与有关更传统的疾病威胁的信息相比,有关新发传染病的信息相当有限。在规划应对新出现的传染病威胁时,应考虑到孕妇对传染病反应的改变。
Immunologic changes of pregnancy may increase susceptibility to certain intracellular pathogens. A key component of the response to emerging infections is consideration of special populations, including pregnant women. Successful pregnancy depends on adaptation of the woman's immune system to tolerate a genetically foreign fetus. Although the immune system changes are not well understood, a shift from cell-mediated immunity toward humoral immunity is believed to occur. These immunologic changes may alter susceptibility to and severity of infectious diseases in pregnant women. For example, pregnancy may increase susceptibility to toxoplasmosis and listeriosis and may increase severity of illness and increase mortality rates from influenza and varicella. Compared with information about more conventional disease threats, information about emerging infectious diseases is quite limited. Pregnant women's altered response to infectious diseases should be considered when planning a response to emerging infectious disease threats.
DOI: 10.1016/0165-0378(96)00977-1
发表时间: 1996-10-01
影响因子: 3.4
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