Short telomeres in short-lived males: what are the molecular and evolutionary causes?
Short telomeres in short-lived males: what are the molecular and evolutionary causes?
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DOI：
10.1111/j.1474-9726.2007.00279.x
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发表时间：
2007-04
期刊：
影响因子：
7.8
通讯作者：
Keller L
中科院分区：
文献类型：
--
作者：
Jemielity S;Kimura M;Parker KM;Parker JD;Cao X;Aviv A;Keller L
端粒长度调节是真核生物细胞维持的一个重要方面，因为端粒缩短会导致许多缺陷，包括细胞分裂受损。尽管端粒长度与某些鸟类的寿命相关，但其在衰老和寿命决定中的可能作用仍然知之甚少。在这里，我们研究了端粒动力学（端粒长度和磨损率的变化）和端粒酶活性的蚂蚁黑Lasius，一个物种中不同群体的个体已经进化出非常不同的寿命。我们发现，寿命较短的雄性的体细胞组织的端粒比寿命较长的蜂王和工蜂的端粒要短得多。这些差异在幼虫发育早期就确立了，很可能是由于雄性的端粒缩短速度比雌性快。然而，工蚁的端粒并不比长寿的蚁后短。我们讨论了各种分子机制，可能导致观察到的性别特异性端粒动力学在蚂蚁，包括细胞分裂，氧化应激和端粒酶活性。此外，我们还讨论了蚂蚁和其他物种中这种模式的进化原因。
Telomere length regulation is an important aspect of cell maintenance in eukaryotes, since shortened telomeres can lead to a number of defects, including impaired cell division. Although telomere length is correlated with lifespan in some bird species, its possible role in aging and lifespan determination is still poorly understood. Here we investigate telomere dynamics (changes in telomere length and attrition rate) and telomerase activity in the ant Lasius niger, a species in which different groups of individuals have evolved extraordinarily different lifespans. We found that somatic tissues of the short-lived males had dramatically shorter telomeres than those of the much longer-lived queens and workers. These differences were established early during larval development, most likely through faster telomere shortening in males compared with females. Workers did not, however, have shorter telomeres than the longer-lived queens. We discuss various molecular mechanisms that are likely to cause the observed sex-specific telomere dynamics in ants, including cell division, oxidative stress and telomerase activity. In addition, we discuss the evolutionary causes of such patterns in ants and in other species.
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DOI：
10.1098/rstb.1991.0028
发表时间：
1991-04-29
影响因子：
6.3
作者：
KIRKWOOD, TBL;ROSE, MR
通讯作者：
ROSE, MR
DOI：
10.1098/rspb.2004.2768
发表时间：
2004-08-07
影响因子：
4.7
作者：
Hall, ME;Nasir, L;Monaghan, P
通讯作者：
Monaghan, P
影响因子：
4.9
作者：
Jemielity, S;Keller, L
通讯作者：
Keller, L
影响因子：
8.3
作者：
Jeanclos, E;Schork, NJ;Aviv, A
通讯作者：
Aviv, A
影响因子：
14.9
作者：
CovielloMcLaughlin, GM;Prowse, KR
通讯作者：
Prowse, KR