Epidemiology of SARS-CoV-2 during the first three waves in Scotland: a national record linkage study.
Epidemiology of SARS-CoV-2 during the first three waves in Scotland: a national record linkage study.
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DOI：
10.1136/jech-2022-219367
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发表时间：
2022-11-08
影响因子：
6.3
通讯作者：
Marsh, Kimberly
中科院分区：
文献类型：
--
作者：
Leslie, Kirstin;Findlay, Beth;Ryan, Theresa;Green, Leonardo, I;Harvey, Ciaran;Whettlock, Alice E.;Bishop, Jen;Hardy, Vicki Ponce;Went, April;Wallace, Lesley;McLeod, Allan;Weir, Amanda;Marsh, Kimberly
苏格兰的早期COVID-19大流行-定义为广泛获得疫苗接种和单克隆抗体治疗之前的时代-可以分为三个不同的浪潮：2020年3月至7月，2020年7月至2021年4月和2021年5月至8月。每一波都受到各种社会限制，以减少疾病传播和相关的发病率和死亡率。了解这些浪潮期间的感染流行病学可以为未来的大流行规划提供宝贵的见解。包括截至2021年8月8日（苏格兰取消大部分限制的前一天）报告的苏格兰RT-PCR检测数据。人口统计学特征，包括年龄，性别和社会剥夺与传播，发病率和死亡率进行了比较。然后对每个波进行病例对照分析，以进一步比较随时间推移与死亡相关的风险因素。在349 904例报告病例中，第1、2和3波分别有18 099、197 251和134 554例。住院、重症监护病房入院和死亡人数在第2波中最高，但与COVID-19死亡相关的风险因素在各波中保持相似。在所有波中，较高的剥夺和某些合并症与较高的死亡率相关。尽管第二波和第三波报告的病例数较高，但病死率较低：这可能是由于更好地发现了较年轻年龄组的感染，采取了社会措施和接种疫苗。较高的社会剥夺和合并症导致所有浪潮的死亡率较高。
The early COVID-19 pandemic in Scotland—defined as the era before widespread access to vaccination and monoclonal antibody treatment—can be characterised into three distinct waves: March–July 2020, July 2020–April 2021 and May–August 2021. Each wave was met with various societal restrictions in an effort to reduce disease transmission and associated morbidity and mortality. Understanding the epidemiology of infections during these waves can provide valuable insights into future pandemic planning. Scottish RT-PCR testing data reported up until 8 August 2021, the day prior to most restrictions being lifted in Scotland, were included. Demographic characteristics including age, sex and social deprivation associated with transmission, morbidity and mortality were compared across waves. A case–control analysis for each wave was then modelled to further compare risk factors associated with death over time. Of the 349 904 reported cases, there were 18 099, 197 251 and 134 554 in waves 1, 2 and 3, respectively. Hospitalisations, intensive care unit admissions and deaths appeared highest in wave 2, though risk factors associated with COVID-19 death remained similar across the waves. Higher deprivation and certain comorbidities were associated with higher deaths in all waves. Despite the higher number of cases reported in waves 2 and 3, case fatality rates were lower: likely a combination of improved detection of infections in younger age groups, introduction of social measures and vaccination. Higher social deprivation and comorbidities resulted in higher deaths for all waves.
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影响因子：
9.3
作者：
Niedzwiedz, Claire L.;O'Donnell, Kate A.;Katikireddi, S. Vittal
通讯作者：
Katikireddi, S. Vittal
影响因子：
15.8
作者：
McKeigue PM;Weir A;Bishop J;McGurnaghan SJ;Kennedy S;McAllister D;Robertson C;Wood R;Lone N;Murray J;Caparrotta TM;Smith-Palmer A;Goldberg D;McMenamin J;Ramsay C;Hutchinson S;Colhoun HM;Public Health Scotland COVID-19 Health Protection Study Group
通讯作者：
Public Health Scotland COVID-19 Health Protection Study Group
影响因子：
10
作者：
Hopkinson, Nicholas S.;Rossi, Niccolo;Falchi, Mario
通讯作者：
Falchi, Mario
影响因子：
17.3
作者：
Agrawal U;Azcoaga-Lorenzo A;Fagbamigbe AF;Vasileiou E;Henery P;Simpson CR;Stock SJ;Shah SA;Robertson C;Woolhouse M;Ritchie LD;Shiekh A;Harrison EM;Docherty AB;McCowan C
通讯作者：
McCowan C
DOI：
10.1016/s1473-3099(21)00566-1
发表时间：
2022-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Haas EJ;McLaughlin JM;Khan F;Angulo FJ;Anis E;Lipsitch M;Singer SR;Mircus G;Brooks N;Smaja M;Pan K;Southern J;Swerdlow DL;Jodar L;Levy Y;Alroy-Preis S
通讯作者：
Alroy-Preis S